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National Repository of Grey Literature

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Quantitative Measurement of Drugs in Biological Samples using Chromatography Methods. Maláková, Jana ; Nobilis, Milan (advisor) ; Polášek, Miroslav (referee) ; Chládek, Jaroslav (referee) Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: PharmDr. Jana Maláková Supervisor: Doc. PharmDr. Milan Nobilis, PhD., Associate Professor of Bioorganic Chemistry. Title of Doctoral Thesis: Quantitative measurement of drugs in biological samples using chromatography methods. The thesis deals with the application of instrumental analytical methods to the quantitative measurement of drugs and their metabolites in biological samples using liquid and gas chromatography. Various procedures of sample preparation were evaluated during optimization of analytical assays. Precipitation of proteins with acetonitrile was employed (analysis of cefuroxime), liquid-liquid extraction (analysis of topiramate, 8-methoxypsoralen) and samples were also purified using a mixed-mode solid-phase extraction (reversed-phase and ion-exchange principle) during the analysis of galantamine and its metabolites. The unbound cephuroxime fraction in the plasma and protein binding were determined using an ultrafiltration method. Chromatography conditions - gas or liquid chromatography- depended on physico-chemical characteristics of a drug. Due to the thermal decomposition of topiramate, derivatization was used to form a more stable methyl... Detailed record

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