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Design of Front Axle Carrier
Lorenc, Petr ; Dundálek, Radim (referee) ; Svída, David (advisor)
This thesis deals with construction proposal of front axle consoles for tractor Zetor Forterra. The aim of this work is to design and construct the 3D console model, which will be put through a solidity analysis. Based on this analysis the console will be optimized according to the solidity needs. The model proposal is realized in the software Pro/Engineer. Following strength calculations are realized in the software Pro/Mechanica.
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Effect of ceramide acyl chain length on the skin permeabillity
Lorenc, Petr ; Vávrová, Kateřina (advisor) ; Hrabálek, Alexandr (referee)
Ceramides that are present in stratum corneum (SC), the uppermost layer of the skin, are responsible for skin barrier function and thus for its permeability for drugs. Their role in the formation of skin barrier has been widely described; however, up to now, their structure-activity relationships have not been fully revealed. Previous studies suggested, that the ceramide acyl chain length is a key factor for the permeability of the skin barrier. The aim of this work was to study the influence of the length of ceramide acyl chain on the permeability of the skin barrier using short ceramides, sphingosine, phytoshingosine and ceramide 2 (NS). Short ceramide analogues contained sphingosine with 18 carbon atoms and the acyl chain ranging from 2 to 18 carbon atoms. Their influence on skin permeability was tested in vitro in Franz diffusion cells on dermatomed porcine skin using two model drugs - theophylline (TH) and indomethacin (IND). Donor samples were prepared as 5% (w/v) suspension of TH and 2.5% (w/v) suspension of IND with addition of 1% (w/v) ceramide in 60% (v/v) propylene glycol. Negative samples for the comparison of the fluxes and the drug concentrations contained 5% (w/v) suspension of TH and 2.5% (w/v) suspension of IND propylene glycol without the addition of ceramide. Phosphate buffer...
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Effect of ceramide acyl chain length on the skin permeabillity
Lorenc, Petr ; Vávrová, Kateřina (advisor) ; Hrabálek, Alexandr (referee)
Ceramides that are present in stratum corneum (SC), the uppermost layer of the skin, are responsible for skin barrier function and thus for its permeability for drugs. Their role in the formation of skin barrier has been widely described; however, up to now, their structure-activity relationships have not been fully revealed. Previous studies suggested, that the ceramide acyl chain length is a key factor for the permeability of the skin barrier. The aim of this work was to study the influence of the length of ceramide acyl chain on the permeability of the skin barrier using short ceramides, sphingosine, phytoshingosine and ceramide 2 (NS). Short ceramide analogues contained sphingosine with 18 carbon atoms and the acyl chain ranging from 2 to 18 carbon atoms. Their influence on skin permeability was tested in vitro in Franz diffusion cells on dermatomed porcine skin using two model drugs - theophylline (TH) and indomethacin (IND). Donor samples were prepared as 5% (w/v) suspension of TH and 2.5% (w/v) suspension of IND with addition of 1% (w/v) ceramide in 60% (v/v) propylene glycol. Negative samples for the comparison of the fluxes and the drug concentrations contained 5% (w/v) suspension of TH and 2.5% (w/v) suspension of IND propylene glycol without the addition of ceramide. Phosphate buffer...
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Design of Front Axle Carrier
Lorenc, Petr ; Dundálek, Radim (referee) ; Svída, David (advisor)
This thesis deals with construction proposal of front axle consoles for tractor Zetor Forterra. The aim of this work is to design and construct the 3D console model, which will be put through a solidity analysis. Based on this analysis the console will be optimized according to the solidity needs. The model proposal is realized in the software Pro/Engineer. Following strength calculations are realized in the software Pro/Mechanica.
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