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Measurement of the skin mechanical properties after application of the anti-aging product
Lejsalová, Alžběta ; Kuchařová, Monika (advisor) ; Ďoubal, Stanislav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of biophysics and physical chemistry Candidate: Mgr. Alžběta Lejsalová Supervisor: Mgr. Monika Kuchařová, PhD. Title of Thesis: Measurement of the skin mechanical properties after application of the anti-aging product The maintaince of youthful skin appearance is strongly desired by the sociaty nowadays. A lot of anti-aging strategies, agents and procedures have been already described but it is difficult to measure the effectiveness of these products and methods. Viscoelastometer developed at the Faculty of Pharmacy in Hradec Králové offers a quick and painless measurement of basic mechanical parameters of the skin, stiffness and viscosity. Previous researches indicate that these parameters vary with age. The aim of this study was to determinate the effect of anti-aging product on these mechanical parameters. Twenty volunteers (women aged 25 - 67 years) used the tested product Vichy Liftactiv Serum 10 twice a day for two months. During the experiment skin mechanical properties were measured at the application site and the obtained values were compared by the t-test. The theoretical part is focused on characterizing the basic anatomical, physiological and biomechanical properties of the skin, describes the aging process...
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Vliv O-glykosylace v onkofetálním fibronektinu na kostní formaci
Lejsalová, Alžběta ; Šimůnek, Tomáš (advisor) ; Pávek, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Performed at Institute of Immunology The Ruprecht-Karls-University Heidelberg Candidate: Alžběta Lejsalová Supervisor: Doc. PharmDr. Tomáš Šimůnek, Ph.D. Specialized supervisor: Prof. Dr. Inaam Nakchbandi Title of diploma thesis: The Influence of the O-glycosylation in oncofetal fibronectin on the bone formation Hepatic osteodystrophy is a major complication in patients with chronic cholestatic liver diseases which significantly contributes to decreased quality of life. It was established that increased levels of the oncofetal domain of fibronectin correlated with bone loss and decrease in bone formation in patients with primary biliary cirrhosis. The oncofetal fibronectin is characterized by the O-glycosylation in the variable domain. Another O-glycosylation is found on the NH2-terminus. The aim of this project was to prepared O-deglycosylated fibronectin isoforms and fibronectin knockdown mammalian cells for further research on the effect of O-glycosylation on the bone formation.
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Measurement of the skin mechanical properties after application of the anti-aging product
Lejsalová, Alžběta ; Kuchařová, Monika (advisor) ; Ďoubal, Stanislav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of biophysics and physical chemistry Candidate: Mgr. Alžběta Lejsalová Supervisor: Mgr. Monika Kuchařová, PhD. Title of Thesis: Measurement of the skin mechanical properties after application of the anti-aging product The maintaince of youthful skin appearance is strongly desired by the sociaty nowadays. A lot of anti-aging strategies, agents and procedures have been already described but it is difficult to measure the effectiveness of these products and methods. Viscoelastometer developed at the Faculty of Pharmacy in Hradec Králové offers a quick and painless measurement of basic mechanical parameters of the skin, stiffness and viscosity. Previous researches indicate that these parameters vary with age. The aim of this study was to determinate the effect of anti-aging product on these mechanical parameters. Twenty volunteers (women aged 25 - 67 years) used the tested product Vichy Liftactiv Serum 10 twice a day for two months. During the experiment skin mechanical properties were measured at the application site and the obtained values were compared by the t-test. The theoretical part is focused on characterizing the basic anatomical, physiological and biomechanical properties of the skin, describes the aging process...
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Vliv O-glykosylace v onkofetálním fibronektinu na kostní formaci
Lejsalová, Alžběta ; Šimůnek, Tomáš (advisor) ; Pávek, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Performed at Institute of Immunology The Ruprecht-Karls-University Heidelberg Candidate: Alžběta Lejsalová Supervisor: Doc. PharmDr. Tomáš Šimůnek, Ph.D. Specialized supervisor: Prof. Dr. Inaam Nakchbandi Title of diploma thesis: The Influence of the O-glycosylation in oncofetal fibronectin on the bone formation Hepatic osteodystrophy is a major complication in patients with chronic cholestatic liver diseases which significantly contributes to decreased quality of life. It was established that increased levels of the oncofetal domain of fibronectin correlated with bone loss and decrease in bone formation in patients with primary biliary cirrhosis. The oncofetal fibronectin is characterized by the O-glycosylation in the variable domain. Another O-glycosylation is found on the NH2-terminus. The aim of this project was to prepared O-deglycosylated fibronectin isoforms and fibronectin knockdown mammalian cells for further research on the effect of O-glycosylation on the bone formation.
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