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Pyrazine derivatives as potential drugs IV
Lešňanská, Katarína ; Doležal, Martin (advisor) ; Opletalová, Veronika (referee)
Title of diploma thesis: Pyrazine derivates as potential drugs IV. Recherché about occurence of tuberculosis in the world, characteristics of this disease, treatment and drugs used was conducted first in this diploma thesis. Methods of preparing substituted pyrazinecarboxylic acid amids were found in chemical literature. Six new compounds, in chemical literature undocumented amides, were synthetized. Prepared products were described using melting temperature, elementary analysis, IR, 1 H and 13 C NMR spectroscopy. Group of compounds was tested in vitro for biological activity. Information about antimycobacterial, antifungal and herbicide activity was gained. Substances lipophilicity was evaluated. Values of log P were counted. At the end, relationship between biological activity, chemical structure and lipophilicity of prepared substances was evaluated.
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Pyrazine derivatives as potential drugs IV
Lešňanská, Katarína ; Opletalová, Veronika (referee) ; Doležal, Martin (advisor)
Title of diploma thesis: Pyrazine derivates as potential drugs IV. Recherché about occurence of tuberculosis in the world, characteristics of this disease, treatment and drugs used was conducted first in this diploma thesis. Methods of preparing substituted pyrazinecarboxylic acid amids were found in chemical literature. Six new compounds, in chemical literature undocumented amides, were synthetized. Prepared products were described using melting temperature, elementary analysis, IR, 1 H and 13 C NMR spectroscopy. Group of compounds was tested in vitro for biological activity. Information about antimycobacterial, antifungal and herbicide activity was gained. Substances lipophilicity was evaluated. Values of log P were counted. At the end, relationship between biological activity, chemical structure and lipophilicity of prepared substances was evaluated.
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