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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Nádorová imunoterapie pankreatického adenokarcinomu založená na synergii agonistů TLR a ligandů stimulujících fagocytózu a její protimetastázový účinek
 LENCOVÁ, Radka
This thesis deals with an immunotherapeutic strategy based on combination of TLR agonists, the ligands stimulating phagocytosis, and monoclonal antibody anti-CD40. The aim of this work was to assess, whether it is possible to improve this immunotherapeutic preparation, either by adding a new component, or in combination with another therapeutic approach. We used IL-2 to stimulate proliferation of cytotoxic T lymphocyte clones. We tried to combine preparation with radiotherapy and with chemotherapy - Vinblastine and Acriflavine. Mechanisms of vaccine were studied on knock-out mice as well.
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Anti-CD47 protilátka v nádorové terapii
 LENCOVÁ, Radka
The aim of this thesis was to answer question whether it is possible to improve the effect of cancer immunotherapy. This is based on the combination of TLR agonists and the ligands stimulating phagocytosis. We used anti-CD47 antibody to block CD47 on tumor cells. The second question was whether it is practicable to reduce the number of vaccine applications.
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