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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Immune response to experimental active immunotherapy DCVac/OvCa in patients with ovarian carcinoma in phase II clinical trials.
 Ksandrová, Marie ; Sadílková, Lenka (advisor) ; Krulová, Magdaléna (referee)
The immunotherapeutic drug DCVAC/OvCa is being tested in the treatment of ovarian cancer patients within the SOV02 clinical trial (Eudra CT number: 2013-001323-38). Ovarian cancer belongs to gynaecological malignancies with the highest mortality rate. Around 60% of patients are diagnosed at advanced stages. Despite the initial successful treatment, relapses occur in most cases, and the disease often becomes resistant to chemotherapy. Effective therapy for relapsed or metastatic patients is still missing. The solution could be immunotherapeutic treatment. DCVAC is an active cellular immunotherapy based on autologous dendritic cells. The aim of this diploma thesis was monitoring of immune parameters in samples from clinical trial SOV02 patients during the time period defined in the study protocol. We have monitored the presence of antigen specific T lymphocytes, tumor specific antibodies, immunosuppressive populations of regulatory T cells and MDSC cells, and also the expression of inhibitory molecules on the surface of T lymphocytes. We observed higher levels of Her-2, Muc-1 and MAGE-A1 antibodies in the DCVAC/OvCa treated group of patients versus the control group. Significant differences in the other monitored parameters were not observed. However, a large amount of data have been obtained that...
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Role of cFLIP/CFLAR protein in the activation and regulation of cell death
 Ksandrová, Marie ; Anděra, Ladislav (advisor) ; Macůrková, Marie (referee)
Programmed cell death as a natural mechanism plays essential role in development and homeostasis maintenance through removal of damaged, unwanted or dangerous cells. The cell death is an irreversible proces must be strictly regulated and thus defects in the regulation of cell death could lead to serious/fatal diseases. There are also one of the reasons why cell death regulating mechanisms are subjects of intense research nowadays. c-FLIP is one of several important cell death regulators. Three distinct isoforms of c-FLIP were detected on the protein level in human organism (long c-FLIPL and two shorter variants c-FLIPS and c-FLIPR) that interact their main cellular partner procaspase 8. The functional consequences of their interaction (enhancement or suppression of procaspase 8 selfprocessing) depend on the cellular level of c-FLIP, expressed splice variants and extracellular signaling. As c-FLIP is an important component of cell death signaling pathways (apoptosis and regulated necrosis), its expression and functional posttranslational modifications are strictly regulated by several mechanisms. Upregulation of c-FLIP levels has been found in various types of tumor cells that are often resistant to anticancer treatment.
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