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Incidence of malignant neoplasms in renal transplant recipients: Association between transplantation and the incidence of skin cancer
Krásová, Martina ; Göpfertová, Dana (advisor) ; Dlhý, Jozef (referee) ; Vašků, Vladimír (referee)
Aims: To determine the incidence of skin cancer and other malignancies in renal transplant recipients (RTRs) transplanted in the largest transplant center in the Czech Republic. To identify the distribution of risk factors involved in the skin cancer development and to derive the optimal strategy for dermatological screening in the Czech transplant population. Materials and methods: A cohort study was performed on the group of 797 patients after kidney transplantation, who were referred for dermatological examination in the time period from January 2013 to January 2016. Standardized morbidity ration (SMR) was analyzed and calculated for different types of cancer developed in the posttransplant period. Results: 192 cases of malignancies were diagnosed in 86 RTRs (10,8 %). Nonmelanoma skin cancer (NMSC) was the most frequent type of cancer with SMR = 6,42 (P = 0,000), followed by renal cancer with SMR = 5,9 (P = 0,000), malignant melanoma with SMR = 2,59 (P = 0,080) and prostate cancer with SMR = 1,21 (P = 0,593). The risk to develop NMSC was significantly higher in the group where cyclosporine has been used besides tacrolimus, mycophenolatemophetil and steroids as well as in the group treated with the combination without cyclosporine (SMR = 9,62, P = 0,001 and SMR = 5,18, P = 0,000). Furthermore,...
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Incidence of malignant neoplasms in renal transplant recipients: Association between transplantation and the incidence of skin cancer
Krásová, Martina ; Göpfertová, Dana (advisor) ; Dlhý, Jozef (referee) ; Vašků, Vladimír (referee)
Aims: To determine the incidence of skin cancer and other malignancies in renal transplant recipients (RTRs) transplanted in the largest transplant center in the Czech Republic. To identify the distribution of risk factors involved in the skin cancer development and to derive the optimal strategy for dermatological screening in the Czech transplant population. Materials and methods: A cohort study was performed on the group of 797 patients after kidney transplantation, who were referred for dermatological examination in the time period from January 2013 to January 2016. Standardized morbidity ration (SMR) was analyzed and calculated for different types of cancer developed in the posttransplant period. Results: 192 cases of malignancies were diagnosed in 86 RTRs (10,8 %). Nonmelanoma skin cancer (NMSC) was the most frequent type of cancer with SMR = 6,42 (P = 0,000), followed by renal cancer with SMR = 5,9 (P = 0,000), malignant melanoma with SMR = 2,59 (P = 0,080) and prostate cancer with SMR = 1,21 (P = 0,593). The risk to develop NMSC was significantly higher in the group where cyclosporine has been used besides tacrolimus, mycophenolatemophetil and steroids as well as in the group treated with the combination without cyclosporine (SMR = 9,62, P = 0,001 and SMR = 5,18, P = 0,000). Furthermore,...
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