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Bioethics I - Nanotechnology in the biomedicíně.
Váchová, Olga ; Kudláčková, Zděnka (advisor) ; Kottová, Martina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of biological and biomedicinal sciences Olga Váchová Supervisor: PhDr. Zdeňka Kudláčková, PhD. Title of diploma tehesis: Bioethics I - Nanotechnology in the biomedicine Background: Create basic summary of ethical theories and bioethics principles. Compile summary of used and investigated nanotechnology applications - particularly their influence on human health and living environment. Furthermore, chart contemporary research and practical nanotechnology use regulation state. Main findings: Nanotechnology is presently one of the fastest developing technologies. Many authors think, that it is a significant breakthrough for society, similar to discovery of steam or electronics in recent history. Usage of nanotechnology is able to considerably extend society potential in material engineering, electronics, optics and particularly in medicine and pharmacy. We can imagine treatment of cancer without side effects of chemotherapy, more sensitive examination methods, durable a biocompatible implants or nanobots monitoring biology functions of human body. Many products and production materials based on nanoparticles or nanotechnology have been commercially exploited until today. Despite of wider and wider applications in daily life,...
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Bioethics I - Nanotechnology in the biomedicíně.
Váchová, Olga ; Kudláčková, Zděnka (advisor) ; Kottová, Martina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of biological and biomedicinal sciences Olga Váchová Supervisor: PhDr. Zdeňka Kudláčková, PhD. Title of diploma tehesis: Bioethics I - Nanotechnology in the biomedicine Background: Create basic summary of ethical theories and bioethics principles. Compile summary of used and investigated nanotechnology applications - particularly their influence on human health and living environment. Furthermore, chart contemporary research and practical nanotechnology use regulation state. Main findings: Nanotechnology is presently one of the fastest developing technologies. Many authors think, that it is a significant breakthrough for society, similar to discovery of steam or electronics in recent history. Usage of nanotechnology is able to considerably extend society potential in material engineering, electronics, optics and particularly in medicine and pharmacy. We can imagine treatment of cancer without side effects of chemotherapy, more sensitive examination methods, durable a biocompatible implants or nanobots monitoring biology functions of human body. Many products and production materials based on nanoparticles or nanotechnology have been commercially exploited until today. Despite of wider and wider applications in daily life,...
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Effect of Selected Substances on the Respiratory System of Rat in Vivo and in Vitro
Kottová, Martina ; Pourová, Jana (advisor) ; Herink, Josef (referee) ; Nosálová, Gabriela (referee)
BACKGROUND: Asthma is a chronic inflammatory disorder of the airways in which a number of cells and cellular elements play a role. It is a lifetime disease which is not completely curable. Many factors contribute to the pathogenesis of asthma, oxidative stress being an important one. In healthy humans, the toxicity of free radicals is inhibited by enzymatic and non-enzymatic systems. In asthmatics, the function of these endogenous systems is impaired. Despite treatment, asthma morbidity and mortality steadily increases. The search for new drugs can be based on the knowledge of the pathological changes associated with the disease, and can also be inspired by folk medicine. As regards the latter approach, new, more potent substances could be obtained by isolation and chemical modification of natural products. The aim of this doctoral thesis was to elucidate the effects of selected substances on the respiratory system of rats by in vivo and in vitro methods. We investigated the effects of orally administered α-tocopherol on the lung response in an in vivo rat model of allergic asthma. The second part of this thesis deals with natural quinazoline alkaloids (Justicia adhatoda standardized extract, vasicine, vasicinone) and their synthetic analogues, and their relaxant effects on an isolated rat trachea. The...
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