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Study of substituted arylguanidines as potential drugs XIV.
 Kobosilová, Jana ; Palát, Karel (advisor) ; Kováčik, Andrej (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Author: Jana Kobosilová Supervisor: PharmDr. Karel Palát, CSc. Title of bachelor thesis: Study of substitued arylguanidines as potencial drugs XIV. In view of the increasing number of fungal pathogens and the increased resistance of these pathogens to already available antifungal agents, a new structure inhibiting the growth of these pathogens must be sought. In the area of guanidine-derived substances, a worldwide research is taking place, which is also attended by the Faculty of Pharmacy in Hradec Králové. As part of my bachelor thesis, five previously unpublished substances have been synthesized: hexadecyl(4-methyl-2-nitrophenyl) sulfide 2-(hexadecylsulfanyl)-5-methylaniline 2-(hexadecylsulfanyl)-5-methylanilinium chloride 2-[2-(hexadecylsulfanyl)-5-methylphenyl]guanidinium nitrate 2-[2-(hexadecylsulfanyl)-5-methylphenyl]-1,1-dimethylguanidine
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