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The Role of Biomerkers Obtainet from Serum, Sputum, BALF and Lung Tissue Saamples in Assessing in Activity and Targeting Therapy of Chronic Inflammantory and Fibrotic Diseases of the Lungs and Bronchi
Kirchnerová, Olga ; Teřl, Milan (advisor) ; Koblížek, Vladimír (referee) ; Rozborilová, Eva (referee)
The role of biomarkers obtained from serum, sputum, BALF and lung tissue samples in assessing the activity and targeting therapy of chronic inflammatory and fibrotic diseases of the lungs and bronchi Introduction Chronic inflammatory and fibrotic lung and airway diseases represent a heterogeneous group of respiratory tract diseases, both with an initial inflammatory background. Crucial differences in its etiopathogenesis and location significantly influence its clinical manifestation. Considering an extensive progression in science, it is obvious that there is certain heterogeneity among inflammatory processes as well as in etiopathogenesis within the differential diagnosis. Nowadays the aim is to choose best-targetted therapy based on specific endotypes and phenotypes. Aims The aim of this study is I) to provide a comprehensive overview of biomarkers of chronic inflammatory and fibrotic lung and bronchi disorders II) to asses a diagnostic role of biomarkers in clinical practice as well as the role of biomarkers when deciding a type of phenotypically targeted therapy in patients with severe refractory asthma. Methods The work (ad II) is divided into two parts. In the first part, we correlated levels of serum biomarkers, biomarkers in induced sputum, bronchoalveolar lavage fluid and ENT findings...
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