|
|
Synthesis of Novel Fused N-Heterocyclic [2.2]Paracyclophanes Using C-H Activation/Annulation
Kepková, Klementýna ; Nečas, David (advisor) ; Matoušová, Eliška (referee)
This bachelor thesis is focused on the development of a new methodology leading to a novel type of N-heterocyclic [2,2]Paracyclophanes (we can also view these compounds as isoquinoline derivatives) based on directed C-H activation/annulation process. Within the thesis, necessary [2,2]Paracyclophane derivatives containing appropriate directing group and non-commercial alkynes have been prepared. Suitable catalytic conditions for the C-H activation/annulation reaction sequence have been found and subsequently optimized. Finally, to demonstrate the applicability of that method, several new N-heterocyclic [2,2]Paracyclophane derivatives have been prepared and characterized successfully. Key words: [2.2]Paracyclophane, C-H activation, annulation, Isoquinoline, directing group
|
guest ::
