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The role of a specific miRNAs in the regulation of apoptosis during physiological and pathophysiological processes in the CNS
Kaslová, Tereza ; Romanyuk, Natalyia (advisor) ; Klassen, Ruslan (referee)
MicroRNAs are small non-coding RNAs of 20 to 24 nucleotides in size that are able to post- transcriptionally regulate gene expression by binding to mRNA. This paper focuses on how these microRNAs are generated and how they are able to regulate at the level of proteins involved in programmed cell death - apoptosis. By what mechanisms apoptosis occurs, what proteins are involved and what changes the cell undergoes are further discussed in this thesis. The precise influence of this post-transcriptional regulation is presented by using selected microRNAs that influence apoptosis during the development of the central nervous system, as well as during and as a consequence of the neurodegenerative diseases and damage that can affect it. Finally, it will also introduce the use of microRNAs as potential biomarkers, due to changes in their levels associated with various diseases, and as direct therapeutic targets. Keywords Apoptosis, microRNA, cell death, central nervous system, neurodegenerative diseases, gene expression regulation
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Strategic analysis of the company
Kaslová, Tereza ; Machek, Ondřej (advisor) ; Nohejl, Martin (referee)
This bachelor thesis focuses on Strategic analysis of the Algon-plus, a.s. company and evaluation of suitable future strategy based on evaluated data. The data is processed on the bases of analyses of external and internal environment. All the original data was provided by Algon Plus-auto company. External environment is represented by the analysis of micro and macro of the company´s surroundings. Here the results of the PEST analyses are primary. Internal environment analysis comprises the analysis of internal resources including financial analysis. In this part the results of SWOT analysis are primary. These identify the weak and the strong aspects of the company, its opportunities and threats. By analysis it was found that financial situation of the company is steadily improving. Algon Plus-auto, a.s. is performing well between current cars manufacturers. To improve its market position the company needs to gain new customers thus creating a strong bond which cannot be threatened by the competition. Information published in this thesis helps to improve orientation in a constantly evolving car industry.
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