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Nádorová imunoterapie a možnosti zesílení jejího účinku
 KVARDOVÁ, Karolína
The aim of this thesis was to study cancer immunotherapy based on combination of TLR7 signalling and activation of phagocytosis of cancer cells. This thesis was focused on the possibility of enhancing its effect. The possibilities of removing immunosuppressive barriers (esp. MDSCs and adenosine) were studied, using a combination with chemotherapy or enzyme - adenosine deaminase and purine nucleoside phosphorylase. The effect of enzymes was studied in both in vivo and in vitro experiments. As another way of optimizing the therapy used so far, the modulation of the therapeutic mixture using lower molecular weight substances was tried.
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Nádorová imunoterapie založená na kombinaci TLR7 signalizace a aktivace fagocytózy nádorových buněk. Studium mechanismů a zesílení účinku
 KVARDOVÁ, Karolína
The aim of this thesis was to study cancer immunotherapy based on combination of TLR7 signalling and activation of phagocytosis of cancer cells. We studied the influence of our immunotheraphy on parallel untreated tumor. Mechanisms of therapy were studied in vitro. The possibility to enhance therapeutic effect using more complex mixture of TLR agonists was studied as well.
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See also: similar author names
1 KVARDOVÁ, Kamila
3 KVARDOVÁ, Kristýna
4 Kvardová, Kateřina
2 Kvardová, Klára
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