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Determination of the plasticity of lactose
Juhaňáková, Jana ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Juhaňáková Jana - Rigorózní práce - 2006 This work deals with the determination of tablet plasticity made of Tablettose 70 using stress relaxation method. Theoretical part of the work describes preparation and characterization of the tablets. It deals in detail with the determination of residual plasticity of Tablettose 70, determination of the influence of the dwell time on residual plasticity and on the dependence of residual plasticity on compression force. Plasticity was measured by means of T1 - -FRO 50 device. From the results of the work it follows that the increase in dwell time results in residual plasticity of Tablettose 70. Tablettose 70 has the parameter A 49.679 % and tangent B -13.712% kN-1 .
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Determination of the Kinetics of the Crushing Process of Tablets Containing Paracetamol
Juhaňáková, Jana ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Juhaňáková Jana - diplomová práce - 2006 The diploma theses deal with the measurement of mechanical resistance of tablets on basis of force - displacement record. The new method compared to the classical method characterizes mechanical resistance by means of destruction and destructive energy. Theoretical part of the work describes characterization and distribution of granules and tablets, characterization of additives used for production of tablets. It deals with the starch group in detail as well. The aim the experimental work was the determination of optimal parameters for measurement of the kinetics of destruction of tablets, preloading, rate of preloading a cycle. Commercially produced tablets of Paralen 500 were evaluated. The optimal parameters for the measurement of mechanical resistance of tablets by means of T1 - FRO 50 by differential record method are the following: preloading 0.1 N, preloading rate 0.1 mm/s, cycle rate 1.0 mm/s
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Determination of the Kinetics of the Crushing Process of Tablets Containing Paracetamol
Juhaňáková, Jana ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Juhaňáková Jana - diplomová práce - 2006 The diploma theses deal with the measurement of mechanical resistance of tablets on basis of force - displacement record. The new method compared to the classical method characterizes mechanical resistance by means of destruction and destructive energy. Theoretical part of the work describes characterization and distribution of granules and tablets, characterization of additives used for production of tablets. It deals with the starch group in detail as well. The aim the experimental work was the determination of optimal parameters for measurement of the kinetics of destruction of tablets, preloading, rate of preloading a cycle. Commercially produced tablets of Paralen 500 were evaluated. The optimal parameters for the measurement of mechanical resistance of tablets by means of T1 - FRO 50 by differential record method are the following: preloading 0.1 N, preloading rate 0.1 mm/s, cycle rate 1.0 mm/s
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Determination of the plasticity of lactose
Juhaňáková, Jana ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Juhaňáková Jana - Rigorózní práce - 2006 This work deals with the determination of tablet plasticity made of Tablettose 70 using stress relaxation method. Theoretical part of the work describes preparation and characterization of the tablets. It deals in detail with the determination of residual plasticity of Tablettose 70, determination of the influence of the dwell time on residual plasticity and on the dependence of residual plasticity on compression force. Plasticity was measured by means of T1 - -FRO 50 device. From the results of the work it follows that the increase in dwell time results in residual plasticity of Tablettose 70. Tablettose 70 has the parameter A 49.679 % and tangent B -13.712% kN-1 .
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