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Effect of food flavonoids on the activity and expression of selected biotransformation enzymes in rat liver and intestine
Jedličková, Pavla ; Szotáková, Barbora (advisor) ; Skálová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Pavla Jedli ková Supervisor: Doc. Ing. Barbora Szotáková, Ph.D. Title of diploma thesis: Effect of food flavonoids on the activity and expression of selected biotrasformation enzymes in rat liver and intestine The use of herbal products in the form of dietary supplements containing a mixture of concentrated anthocyanins, the important class of flavonoids, is still increasing. This fact leads to research and characterisation of the interaction of these bioactive compounds with the bitransformation system of living organisms. Changes in the activity and the expression of phase I and II biotransformation enzymes caused by flavonoids may affect pharmacokinetic and pharmacodynamic profiles of co- administered drugs. So may be impaired the safety and efficacy of pharmacotherapy. In this study several groups of rats were in vivo treated with extract of a food supplement Urinal Akut® containing flavonoids from cranberry (Vaccinium macrocarpon Ait.). The aim of this study was to evaluate the effect of flavonoids contained in the extract on activity and expression of intestinal and hepatic enzymes: cytochrome P450 (CYP3A, CYP1A1, CYP1A2, CYP2B), carbonyl reductase 1 (CBR1), glutathione...
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