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The employment of HPLC in the field of chiral separations III.
Janetková, Monika ; Kučera, Radim (advisor) ; Nobilis, Milan (referee)
Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University Candidate: Monika Janetková Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: doc. Ing. Radim Vespalec, DrSc. Title of Thesis: The employment of HPLC in the field of chiral separations III. Boron cluster compounds are completely synthetic inorganic structures posessing unique properties. Exceptional characteristics allow them to prove competent among organic molecules predominantely used in medicine. Basic structure is made of boron and hydrogen atoms forming three-dimensional polyhedron with triangular planes. The atoms B-H-B are forming electrondeficient three-centred two-electron bond. Cloud of electrons that is shared inside polyhedron structure is the cause of delocalized negative charge of a whole molecule. Boron cluster compounds are likely to loose hydrogen proton in both, protic and aprotic solvents, ending in formation of an anion. Among their typical characteristics belong extreme hydrophobicity, metabolic and thermal stability. Considering stability and reactivity closo-, nido- and arachno-clusters with 11-12 vertices are largely used. Either of endo- or exoskeletal substitution might impair symmetry of a boron cluster molecule resulting in a formation of...
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The employment of HPLC in the field of chiral separations III.
Janetková, Monika ; Kučera, Radim (advisor) ; Nobilis, Milan (referee)
Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University Candidate: Monika Janetková Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: doc. Ing. Radim Vespalec, DrSc. Title of Thesis: The employment of HPLC in the field of chiral separations III. Boron cluster compounds are completely synthetic inorganic structures posessing unique properties. Exceptional characteristics allow them to prove competent among organic molecules predominantely used in medicine. Basic structure is made of boron and hydrogen atoms forming three-dimensional polyhedron with triangular planes. The atoms B-H-B are forming electrondeficient three-centred two-electron bond. Cloud of electrons that is shared inside polyhedron structure is the cause of delocalized negative charge of a whole molecule. Boron cluster compounds are likely to loose hydrogen proton in both, protic and aprotic solvents, ending in formation of an anion. Among their typical characteristics belong extreme hydrophobicity, metabolic and thermal stability. Considering stability and reactivity closo-, nido- and arachno-clusters with 11-12 vertices are largely used. Either of endo- or exoskeletal substitution might impair symmetry of a boron cluster molecule resulting in a formation of...
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