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Video as a didactic aid for inclusion on secondary school
Janíček, Pavel ; Brdička, Bořivoj (advisor) ; Jeřábek, Tomáš (referee)
This diploma thesis compares (through the method of action research) the impact of using video tutorials with text manuals. The chosen content represented the programming by means of KODU Game Lab with text manuals and MINECRAFT Education Edition with the instructions in the form of video tutorials. At the end of each issue, students were assigned two tasks to work out. Their success rate results were subsequently evaluated. The influence of video tutorials was related to secondary school students: to those with special educational needs, long- term ill pupils and gifted athletes with extensive absence from school. The research in empirical part has proved that video tutorial is preferred learning tool rather than text materials; therefore, it should be considered as an important potential method for the individualization of teaching process. The implementation of video tutorials has obviously helped to make the learning outcomes of SEN students better. It can therefore be stated that video has a potential to serve as a prospective tool for the efficient inclusion of these pupils.
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Multipotent mesenchymal stromal cells in orthopedic: Potentiation of bone healing
Stehlík, David ; Trč, Tomáš (advisor) ; Janíček, Pavel (referee) ; Sedmera, David (referee)
The aim of the thesis was development of an innovative treatment of bone defects. Human multipotent mesenchymal stromal cells (MSC) play a crucial role in bone healing. Clinical applications of MSC require large amount of cells, which could be obtained by autologous expansion of MSC harvested from bone marrow. As a first step, the standard protocol of MSC expansion based on αMEM medium and fetal bovine serum (FBS) was used. Experiments replacing FBS by pooled human serum (HS) in the culture medium concluded in patenting of a new MSC cultivation protocol (EU 1999250, CR 301141). This one-step cultivation protocol and xenogeneic protein-free cultivation medium is based on CellGro® for Hematopoietic Cells' Medium, HS, human recombinant growth factors, dexamethasone, insulin and ascorbic acid. The preclinical in vitro and in vivo experiments with MSC from both expansion protocols were carried out. Fibrillar polylactic scaffolds were seeded with MSC, cultured, differentiated and implanted in immunodeficient mice (NOD/LtSz-Rag1-). Bone-like mineralized tissue containing vessels was observed. The MSC cultured according to patented method were classified as Advanced-therapy Medicinal Product and has to fulfil the European Medicines Agency regulations to enter the clinical trials. Nevertheless the use of MSC seems...
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Video as a didactic aid for inclusion on secondary school
Janíček, Pavel ; Brdička, Bořivoj (advisor) ; Jeřábek, Tomáš (referee)
This diploma thesis compares (through the method of action research) the impact of using video tutorials with text manuals. The chosen content represented the programming by means of KODU Game Lab with text manuals and MINECRAFT Education Edition with the instructions in the form of video tutorials. At the end of each issue, students were assigned two tasks to work out. Their success rate results were subsequently evaluated. The influence of video tutorials was related to secondary school students: to those with special educational needs, long- term ill pupils and gifted athletes with extensive absence from school. The research in empirical part has proved that video tutorial is preferred learning tool rather than text materials; therefore, it should be considered as an important potential method for the individualization of teaching process. The implementation of video tutorials has obviously helped to make the learning outcomes of SEN students better. It can therefore be stated that video has a potential to serve as a prospective tool for the efficient inclusion of these pupils.
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Multipotent mesenchymal stromal cells in orthopedic: Potentiation of bone healing
Stehlík, David ; Trč, Tomáš (advisor) ; Janíček, Pavel (referee) ; Sedmera, David (referee)
The aim of the thesis was development of an innovative treatment of bone defects. Human multipotent mesenchymal stromal cells (MSC) play a crucial role in bone healing. Clinical applications of MSC require large amount of cells, which could be obtained by autologous expansion of MSC harvested from bone marrow. As a first step, the standard protocol of MSC expansion based on αMEM medium and fetal bovine serum (FBS) was used. Experiments replacing FBS by pooled human serum (HS) in the culture medium concluded in patenting of a new MSC cultivation protocol (EU 1999250, CR 301141). This one-step cultivation protocol and xenogeneic protein-free cultivation medium is based on CellGro® for Hematopoietic Cells' Medium, HS, human recombinant growth factors, dexamethasone, insulin and ascorbic acid. The preclinical in vitro and in vivo experiments with MSC from both expansion protocols were carried out. Fibrillar polylactic scaffolds were seeded with MSC, cultured, differentiated and implanted in immunodeficient mice (NOD/LtSz-Rag1-). Bone-like mineralized tissue containing vessels was observed. The MSC cultured according to patented method were classified as Advanced-therapy Medicinal Product and has to fulfil the European Medicines Agency regulations to enter the clinical trials. Nevertheless the use of MSC seems...
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