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Design of MP3 player
Hudáková, Kristína ; Sládek, Josef (referee) ; Zvonek, Miroslav (advisor)
Thesis deals with design of modern MP3 player, it‘s practical and aesthetical purpose. Thesis is based on historical, technical and design analysis of MP3 players currently available on market. Designed MP3 player is worn on wrist as a bracelet and uses wireless technology for transmission between device and headphones. Thesis brings a new viewpoint on consumer electronics while focusing on practical and safe use and importance of aesthetics, ergonomy and interesting design. MP3 players and consumer electronics has become a subject to common use and therefore it should be percieved this way.
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Design of telescope
Hudáková, Kristína ; Paliatka, Peter (referee) ; Sládek, Josef (advisor)
The diploma thesis deals with a design solution of an astronomical mirror telescope, also called Newton reflector on the Dobson Altazimuth mount. The design focuses on the determination of appropriate optic parameters and mounting parameters, on the new styling and shape solution with an emphasis on technical, operational, ergonomic and aesthetic requirements. The main benefit of the design is the simplicity of compilation and decompilation of entire device, intuitive control and safe usage and shape compactness of the whole appliance. I designed the device in the light of the fact that it is used mainly in complete darkness, and the colour solution corresponds to the fact.
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In vitro evaluation of novel Toll-like receptor ligands I.
Hudáková, Kristína ; Trejtnar, František (advisor) ; Soukup, Ondřej (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Kristína Hudáková Supervisor: doc. PharmDr. František Trejtnar, CSc. Title of diploma thesis: In vitro evaluation of novel Toll-like receptor ligands I Vaccination against preventable infections prevents millions of deaths each year. Their immunity enhancing activity is strengthened by the presence of vaccine adjuvants. Development of vaccine adjuvants leads to improved safety profile and also can play a vital role in the research of new vaccines against pathogens against which the vaccines currently do not exist. The main aim of this diploma thesis was to verify the ability of rationally developed small molecule ligands to influence Toll-like receptors and thus their potential to be utilized as vaccine adjuvants. The assay was carried out using modified cell lines continually expressing the human TLR4 or TLR8 whose activation leads to production of secreted embryonic alkaline phosphatase. Ten analyzed substances labelled as DM 001 - DM 010 were examined for their agonistic and also antagonistic properties while interacting with the TLRs. Immunomodulatory activity of these tested samples was then determined by quantification of secreted alkaline phosphatase with the help of a colorimetric...
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In vitro evaluation of novel Toll-like receptor ligands I.
Hudáková, Kristína ; Trejtnar, František (advisor) ; Soukup, Ondřej (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Kristína Hudáková Supervisor: doc. PharmDr. František Trejtnar, CSc. Title of diploma thesis: In vitro evaluation of novel Toll-like receptor ligands I Vaccination against preventable infections prevents millions of deaths each year. Their immunity enhancing activity is strengthened by the presence of vaccine adjuvants. Development of vaccine adjuvants leads to improved safety profile and also can play a vital role in the research of new vaccines against pathogens against which the vaccines currently do not exist. The main aim of this diploma thesis was to verify the ability of rationally developed small molecule ligands to influence Toll-like receptors and thus their potential to be utilized as vaccine adjuvants. The assay was carried out using modified cell lines continually expressing the human TLR4 or TLR8 whose activation leads to production of secreted embryonic alkaline phosphatase. Ten analyzed substances labelled as DM 001 - DM 010 were examined for their agonistic and also antagonistic properties while interacting with the TLRs. Immunomodulatory activity of these tested samples was then determined by quantification of secreted alkaline phosphatase with the help of a colorimetric...
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In vitro evaluation of novel Toll-like receptor ligands I.
Hudáková, Kristína ; Trejtnar, František (advisor) ; Soukup, Ondřej (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Kristína Hudáková Supervisor: doc. PharmDr. František Trejtnar, CSc. Title of diploma thesis: In vitro evaluation of novel Toll-like receptor ligands I Vaccination against preventable infections prevents millions of deaths each year. Their immunity enhancing activity is strengthened by the presence of vaccine adjuvants. Development of vaccine adjuvants leads to improved safety profile and also can play a vital role in the research of new vaccines against pathogens against which the vaccines currently do not exist. The main aim of this diploma thesis was to verify the ability of rationally developed small molecule ligands to influence Toll-like receptors and thus their potential to be utilized as vaccine adjuvants. The assay was carried out using modified cell lines continually expressing the human TLR4 or TLR8 whose activation leads to production of secreted embryonic alkaline phosphatase. Ten analyzed substances labelled as DM 001 - DM 010 were examined for their agonistic and also antagonistic properties while interacting with the TLRs. Immunomodulatory activity of these tested samples was then determined by quantification of secreted alkaline phosphatase with the help of a colorimetric...
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Design of telescope
Hudáková, Kristína ; Paliatka, Peter (referee) ; Sládek, Josef (advisor)
The diploma thesis deals with a design solution of an astronomical mirror telescope, also called Newton reflector on the Dobson Altazimuth mount. The design focuses on the determination of appropriate optic parameters and mounting parameters, on the new styling and shape solution with an emphasis on technical, operational, ergonomic and aesthetic requirements. The main benefit of the design is the simplicity of compilation and decompilation of entire device, intuitive control and safe usage and shape compactness of the whole appliance. I designed the device in the light of the fact that it is used mainly in complete darkness, and the colour solution corresponds to the fact.
|
|
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Design of MP3 player
Hudáková, Kristína ; Sládek, Josef (referee) ; Zvonek, Miroslav (advisor)
Thesis deals with design of modern MP3 player, it‘s practical and aesthetical purpose. Thesis is based on historical, technical and design analysis of MP3 players currently available on market. Designed MP3 player is worn on wrist as a bracelet and uses wireless technology for transmission between device and headphones. Thesis brings a new viewpoint on consumer electronics while focusing on practical and safe use and importance of aesthetics, ergonomy and interesting design. MP3 players and consumer electronics has become a subject to common use and therefore it should be percieved this way.
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