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Effect of albendazole on activity of biotransformation enzymes in lancet fluke
Hradecká, Aneta ; Szotáková, Barbora (advisor) ; Skálová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Title, name, surname of aspirant: Aneta Hradecká Title, name, surname of supervizor: Doc. Ing. Barbora Szotáková, Ph.D. Title of diploma thesis: Effect of albendazole on activity of biotransformations enzymes in lancet fluke Disease caused by lancet flukes, dicrocoeliosis, can lead to dicrease of ruminants utility and consequently to economic loses. Albendazole (the benzimidazole anthelmentic) is one of the most important drugs being used in therapy of dicrocoeliosis. Because of the need to use high and repeated dosage of albendazole, a drug resistance can occure. The aim of present thesis was to determine the influence of albendazole on lancet fluke biotransformation enzyme activity. In this experiment, lancet flukes isolated from the liver of mouflons were used. One group of lancet flukes was incubated with albendazole, another group was used as a control sample. The enzyme activity of chosen enzymes (flavine-containing monooxygenases, carbonyl-reducing enzymes, glutathione S-transferases, UDP-glucuronosyl transferases, UDP-glucosyl transferases) was determined in cytosolic fraction, mitochondria and microsomes of both groups of parazites. In the majority of cases, albendazole did not affect the...
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Effect of albendazole on activity of biotransformation enzymes in lancet fluke
Hradecká, Aneta ; Skálová, Lenka (referee) ; Szotáková, Barbora (advisor)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Title, name, surname of aspirant: Aneta Hradecká Title, name, surname of supervizor: Doc. Ing. Barbora Szotáková, Ph.D. Title of diploma thesis: Effect of albendazole on activity of biotransformations enzymes in lancet fluke Disease caused by lancet flukes, dicrocoeliosis, can lead to dicrease of ruminants utility and consequently to economic loses. Albendazole (the benzimidazole anthelmentic) is one of the most important drugs being used in therapy of dicrocoeliosis. Because of the need to use high and repeated dosage of albendazole, a drug resistance can occure. The aim of present thesis was to determine the influence of albendazole on lancet fluke biotransformation enzyme activity. In this experiment, lancet flukes isolated from the liver of mouflons were used. One group of lancet flukes was incubated with albendazole, another group was used as a control sample. The enzyme activity of chosen enzymes (flavine-containing monooxygenases, carbonyl-reducing enzymes, glutathione S-transferases, UDP-glucuronosyl transferases, UDP-glucosyl transferases) was determined in cytosolic fraction, mitochondria and microsomes of both groups of parazites. In the majority of cases, albendazole did not affect the...
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Specifics of Marketing Communication of American IT company on the European market
Hradecká, Aneta ; Vávra, Oldřich (advisor) ; Bič, Josef (referee)
This master thesis deals with the specifics of marketing communication of American IT company on the European market. The aim of this work is to describe principles of marketing and marketing communication. The main objective of this work is the analysis of Hewlett Packard Enterprise marketing communication, its evaluation and formulation of recommendations that would lead to more effective marketing communication. The benefit of this thesis should be creating comprehensive view of the company, analysis of its communication and subsequent suggestions for improvement, which could be applied in practice.
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Proposal for Sustainable Development of Urban Green Areas in Litoměřice
Hradecká, Aneta ; Vacek, Oldřich (advisor) ; Jiří, Jiří (referee)
Thesis deals with a proposal for sustainable development of urban green areas in Litoměřice. Aim is to provide suitable conditions to guarantee a long term aesthetis value of cultivated trees and the trees stability in the individual town zones so they are not potentionally dangerous to properties or personal health.
Urban green areas are an inseparable part of modern towns and cities. They create favourable living conditions. These areas has positive impact on microclimate in towns; influence psychological and mental state of inhabitans. Therefore, we should take care of those areas and make an effort to keep them functional and in high-quality conditions. Unfortunately, green areas in towns are exposed to a number of negative factors that have an immense impact on their value as well as lifespan. Among the greatest problems belong salinization of soil along motorways, dogs urine, transport, building operations, warm microclimate, soil and air pollution. In order to perserve quality of cultivated trees, towns need to systematically manage and look after green areas. Thus, a concept for maintenance of green areas has been developed, in which the green areas in Litoměřice were divided into eight zones. This concept includes recommendation of suitable selection of trees and their length of life cycle. Concept also presents development of individual zones depending on their character and utilization. Public green areas are proposed to become a part of maitenance system. Project offers a possible way of better care for green areas and maitain their appropriate conditions.
Proposal brings changes into concept of urban green areas maintenance, which needs also the inhabitans understanding and change of their attitude. Overall change can improve environment in towns and provide them with sustainable system of the quality urban green areas.
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Corporate culture of Hewlett-Packard
Hradecká, Aneta ; Müllerová, Františka (advisor) ; Figallová, Jana (referee)
This thesis deals with the corporate culture of the company Hewlett-Packard. The thesis is divided into theoretical and practical parts and consists of five main chapters. The ami is to explain what the corporate culture is and acquaint the reader with a corporate culture of HP. My aim is also to determinate the type of corporate culture of this company according to R. Marr and establish a typology of culture by T. B. Deal and A. A. Kennedy. Based on the survey I analyzed the strength and type of corporate culture.
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