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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
NMDA receptors outside CNS and their subunit composition
 Hotovec, Matěj ; Kolcheva, Marharyta (advisor) ; Horáková, Olga (referee)
N-Methyl-D-Aspartate receptors (NMDARs) are a type of ionotropic glutamate receptor that is widely present in the central nervous system and in lesser numbers in other parts of the body, including the gastrointestinal tract. NMDARs play a crucial role in various physiological and pathological processes in the CNS, including synaptic plasticity, learning and memory, and excitotoxic damage. The role of NMDARs outside the CNS is still under investigation. This thesis aims to confirm the presence of NMDARs in the gastrointestinal tract and their subunit composition. Subunit specific NMDAR modulators showed effect on spontaneous phasic activity of ileum, indirectly confirming the presence of GluN1, GluN2A-D and GluN3 subunits. Attempt at direct evidence of protein expression by immunolabeling with monoclonal antibodies against NMDAR subunits was unsuccessful.
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Neuroprotective effects of ketamine and memantine on NMDA receptors from molecular to systemic level
 Hotovec, Matěj ; Horák, Martin (advisor) ; Spišská, Veronika (referee)
The goal of this thesis is to present the evidence for the role of NMDA receptor excitotoxicity in pathology of Alzheimer's disease, epilepsy, major depressive disorder and ischemic stroke, evaluate the neuroprotective effects of NMDA receptor antagonists ketamine and memantine based on excitotoxicity research, and review the current body of evidence on their potential use as a treatment for these conditions. Keywords: excitotoxicity, ketamine, memantine, NMDAR, neurodegeneration.
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