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National Repository of Grey Literature

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CK1 family kinases and their role in Wnt signalling Horázná, Daniela ; Macůrková, Marie (advisor) ; Folk, Petr (referee) Wnt signalizace je velmi důležitou drahou pro vývoj a růst buněk. V člověka obsahuje šest proteinů různých funkcí a struktur, kódovaných různými geny. Signalizační kaskáda začíná vazbou molekuly Wnt na receptory cílové buňky. Tím je zahájen složitý řetězec navazujících a vzájemně se ovlivňujících reakcí, poháněný a zároveň inhibovaný aktivitou CK1 kináz. Každá kináza má v ignalizaci jinou funkci, ale jejich funkce se mohou překrývat. Za určitých podmínek mohou některé změnit své chování z aktivačního na inhibiční. Tato práce se pokouší rozebrat CK1 členy jednotlivě a ukazuje jejich úlohy ve Wnt signalizaci podle nejnovějších vědeckých poznatků. Detailed record

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