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Treatment of schizophrenia
Hlinková, Lucie ; Hrdina, Radomír (advisor) ; Herink, Josef (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Lucie Hlinková Supervisor: Prof. MUDr. Radomír Hrdina, CSc. Title of diploma thesis: Treatment of schizophrenia Schizophrenia is a serious mental disease, mostly chronic. It affects about 1 % of population, first episode of the disease occurs mostly between the age of 15 and 35. It manifests itself with disorders of perception, behavior and thinking. The specific symptoms include hallucinations, delusions, disorganized speech and behavior, catatonia, disorders of attention and volition and social withdrawal. Etiopathogenesis of schizophrenia is likely affected by both genetic and environmental factors, the true cause of the disease has not been discovered yet. The goal of the treatment is to improve the patient's quality of life and prevent the occurrence of relapses. Drugs acting on the dopaminergic system are effective in the treatment of schizophrenia, where as antagonists bind to the dopamine receptors. These medicines are called antipsychotics, they are divided into two generations. The first generation is characterized by high affinity mainly for dopamine receptors, the second one in addition by binding to serotonin receptors. Each class of antipsychotics is characterized by the...
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