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Peripherally substituted subphthalocyanines for photodynamic therapy with benzocrown or tyrosine methyl ester as axial ligands
Hlbočanová, Ingrid ; Macháček, Miloslav (advisor) ; Šimůnek, Tomáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Science Candidate: BSc. Ingrid Hlbočanová Supervisor: RNDr. Miloslav Macháček, Ph.D. Title of diploma thesis: Peripherally substituted subphtalocyanines for photodynamic therapy with benzocrown or tyrosine methyl ester as axial ligands Tumor diseases are slowly but surely becoming the most widespread disease in the world. Malignant conditions affect a wide range of people who inherited a predisposition to the disease genetically, or were influenced by environmental factors. However, expensive therapy is a problem not only in developed countries, but especially in third world countries. Financial aspect and availability are only part of the problem. Early diagnosis, prevention before the onset of this type of disease and effective therapy are the key elements to succesfull treatment. Due to the high prevalence and mortality associated with malignant diseases, which are increasing every year, great efforts are devoted to the prevention of these diseases and the correct and timely diagnosis associated with a healthy lifestyle. Great attention is also paid to the research and development of new and effective anti-tumor drugs and therapeutic approaches. One such modern and promising method is photodynamic therapy (PDT)....
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Peripherally substituted subphthalocyanines for photodynamic therapy with benzocrown or tyrosine methyl ester as axial ligands
Hlbočanová, Ingrid ; Macháček, Miloslav (advisor) ; Šimůnek, Tomáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Science Candidate: BSc. Ingrid Hlbočanová Supervisor: RNDr. Miloslav Macháček, Ph.D. Title of diploma thesis: Peripherally substituted subphtalocyanines for photodynamic therapy with benzocrown or tyrosine methyl ester as axial ligands Tumor diseases are slowly but surely becoming the most widespread disease in the world. Malignant conditions affect a wide range of people who inherited a predisposition to the disease genetically, or were influenced by environmental factors. However, expensive therapy is a problem not only in developed countries, but especially in third world countries. Financial aspect and availability are only part of the problem. Early diagnosis, prevention before the onset of this type of disease and effective therapy are the key elements to succesfull treatment. Due to the high prevalence and mortality associated with malignant diseases, which are increasing every year, great efforts are devoted to the prevention of these diseases and the correct and timely diagnosis associated with a healthy lifestyle. Great attention is also paid to the research and development of new and effective anti-tumor drugs and therapeutic approaches. One such modern and promising method is photodynamic therapy (PDT)....
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Experimental evaluation of photodynamic efficiency of phthalocyanine photosensitisers and cell death assessment.
Hlbočanová, Ingrid ; Macháček, Miloslav (advisor) ; Kollárová, Petra (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Science Candidate: Ingrid Hlbočanová Supervisor: RNDr. Miloslav Macháček, Ph.D. Title of bachelor thesis: Experimental evaluation of photodynamic efficiency of phthalocyanine photosenzitisers and cell death assessment Tumor diseases represent on of the largest group of malignant illnesses in the world. Their incidence is slowly shifting from developed countries to third world countries and therefore they represent the most widespread health problems, often leading to the death of patients. Intensive research and development of new and effective anticancer drugs and treatment methods is devoted because of the spread and mortality of these diseases. One of the intensively researched modern method is photodynamic therapy (PDT), which is utilizing photosenzitizers (PSs). To ensure the maximum efficiency, effectiveness of PDT and maximalization of results, it is necessary to observe three basic parameters - effective PS, light and oxygen. These individual components do not represent danger to the patients on their own, but their combination brings positive effect in the cancer treatment. The principle of the method is administration of an inactive PS to the patient with subsequent irradiation by light of suitable...
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