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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Using proteomics for screening of potential breast cancer biomarkers
 Garcia N Dua, Felicita ; Ing.Anna Kubesová, Ph.D. (referee) ; Flodrová, Dana (advisor)
Breast cancer is one of the most common malignant cancers and the prognosis is closely related to the stage of carcinogenesis process in which it was captured. Lately, attention was focused on the research of new compounds that would reduce the negative impacts of chemotherapy. It was found that retinoids are effective compounds in the fight against cancer. Retinoids have the ability to inhibit tumors of the mammary gland in an early stage of disease. This work deals with the proteomic studies of breast cancer cells and comparing the proteins contained in the cancer cells which were subjected to retinoid therapy. The differences in protein composition were investigated using gel electrophoresis, reversed phase and size exclusion liquid chromatography. The identification and characterization of selected proteins was carried out by MALDI-TOF MS. The use of two-dimensional gel electrophoresis led to the identification of molecular chaperons, which are considered to be important biomarkers not only of breast cancer.
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