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Synthesis of Precursors for Biologically Active Lactones II
Finková, Lenka ; Kučerová, Marta (advisor) ; Opletalová, Veronika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control In the theoretical part of the diploma paper there are summarized antiviral effects of butenolides isolated from natural resources as well as substances obtained by synthesis. Methyl-(E)-2,3-dibromacrylate has been synthesized within the scope of the experimental work as a precursor for methyl-(E)-2-brom-5-subst.phenylpent-2-en-3- ynoates which have been obtained by Sonogashira coupling with different alkynes. Syntheses of some derivates have been optimized by modification of reaction conditions. Methyl-(E)-2-brom-5-subst.phenylpent-2-en-3-ynoates can be used as starting compounds for synthesis of potential biological active lactones.
Synthesis of Precursors for Biologically Active Lactones II
Finková, Lenka ; Kučerová, Marta (advisor) ; Opletalová, Veronika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control In the theoretical part of the diploma paper there are summarized antiviral effects of butenolides isolated from natural resources as well as substances obtained by synthesis. Methyl-(E)-2,3-dibromacrylate has been synthesized within the scope of the experimental work as a precursor for methyl-(E)-2-brom-5-subst.phenylpent-2-en-3- ynoates which have been obtained by Sonogashira coupling with different alkynes. Syntheses of some derivates have been optimized by modification of reaction conditions. Methyl-(E)-2-brom-5-subst.phenylpent-2-en-3-ynoates can be used as starting compounds for synthesis of potential biological active lactones.

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3 Finková, Lucie
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