National Repository of Grey Literature 4 records found  Search took 0.00 seconds. 
Molecular adaptations of neurotropic and visceral bird schistosomes during the infection of the avian definitive host
Leontovyč, Roman ; Kašný, Martin (advisor) ; Grevelding, Christoph G. (referee) ; Franta, Zdeněk (referee)
Genus Schistosoma is one the most studied group of helminths due to the importance of several representatives in terms of veterinary and human health. The advent of the modern sequencing technologies, as well as the increasing computational capacities, enabled large-scale screening of nucleic acids and thus deep exploration of complex transcriptome and genome information. To date the main attention of leading molecular parasitological "Schistosoma" research teams was focused on serious human pathogens Schistosoma mansoni, Schistosoma japonicum and Schistosoma haematobium. In the term of molecular/biochemical research, the other schistosomatids were mostly neglected and general knowledge was limited to characterization of particular genes/proteins without further link to biological functional complex. Presented thesis summarises the first large-scale insights into the molecular basis of biological principles of two bird schistosomes Trichobilharzia regenti and Trichobilharzia szidati during their invasion of the definitive avian host. While T. szidati uses the "classical" visceral way of migration - bloodstream and lungs (same as human schistosomes), T. regenti, migrates trough the peripheral nerves and spinal cord. Neurotropic migration is unique among schistosomes and it is also extremely rare...

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