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Properties of lecithin nanoemulsions with polysorbate and polyglycerols.
Drdová, Kateřina ; Doležal, Pavel (advisor) ; Berka, Pavel (referee)
Properties of lecitin based nanoemulsions containing polysorbate and polyglyceroles Nanoemulsions, one of the lipid nanodispersions, increase bioavailability of lipophilic drugs, due to their small particle size enable drug targgetting and reduce adverse effects of many drugs. Nanoemulsions are suitable for oral, parenteral, topical and transdermal administration. Essential component of each nanoemulsion is the surfactant. Surfactant has to be chosen very carefully depending on the route of administration, type of the effective substance and other excipients. Choice of surfactant and producing method determine storage stability of final product. Influence of polysorbate 80 and polyglycerol-3-oleate in concentration of 1 %, 0,5 %, 0,1 % and 0,05 % on stability during temperature cycling was observed. Samples were exposed to the temperature 40 řC for 8 hours and 5 řC for 14 hours in turns for time period of 30 days. Particle size and zeta potential were measured and macroscopical changes of samples were observed in defined time intervals. Samples containing polyglycerol as a co-surfactant have shown smaller particle size and smaller size distribution than the samples containing polysorbate. Particle size and size distribution became smaller in time, there were also more excessive macroscopical changes due to...
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Properties of lecithin nanoemulsions with polysorbate and polyglycerols.
Drdová, Kateřina ; Berka, Pavel (referee) ; Doležal, Pavel (advisor)
Properties of lecitin based nanoemulsions containing polysorbate and polyglyceroles Nanoemulsions, one of the lipid nanodispersions, increase bioavailability of lipophilic drugs, due to their small particle size enable drug targgetting and reduce adverse effects of many drugs. Nanoemulsions are suitable for oral, parenteral, topical and transdermal administration. Essential component of each nanoemulsion is the surfactant. Surfactant has to be chosen very carefully depending on the route of administration, type of the effective substance and other excipients. Choice of surfactant and producing method determine storage stability of final product. Influence of polysorbate 80 and polyglycerol-3-oleate in concentration of 1 %, 0,5 %, 0,1 % and 0,05 % on stability during temperature cycling was observed. Samples were exposed to the temperature 40 řC for 8 hours and 5 řC for 14 hours in turns for time period of 30 days. Particle size and zeta potential were measured and macroscopical changes of samples were observed in defined time intervals. Samples containing polyglycerol as a co-surfactant have shown smaller particle size and smaller size distribution than the samples containing polysorbate. Particle size and size distribution became smaller in time, there were also more excessive macroscopical changes due to...
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