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Indicators of Coeliac Disease Activity
Douda, Ladislav ; Tachecí, Ilja (advisor) ; Hucl, Tomáš (referee) ; Falt, Přemysl (referee)
Coeliac disease is a relatively common disorder that has been associated with a worldwide increase in prevalence in recent decades, with potentially serious medical, economic, psychological, and social consequences. At the same time, the high proportion of undiagnosed cases is well known and carries significant additional health risks for the future. In view of this, the introduction of new diagnostic, monitoring and therapeutic options into clinical practice is an important prerequisite for successfully combating this potentially serious disease. The aim of this study was to analyze plasma levels of the amino acids citrulline and ornithine - as potential markers of small intestinal disease activity, marginal zone memory B cell levels - as an indicator of the severity of hyposplenism, and fecal gliadin 33-mer concentration - as an indicator of adherence to a gluten-free diet - in patients followed for celiac disease. We performed an analysis of patients dispensed in gastroenterology outpatient clinics of the 2nd Dpt of Internal Medicine - Gastroenterology (University Hospital and Faculty of Medicine in Hradec Králové, Charles University). We examined the following number of patients within individual subanalyses: for plasma citrulline and ornithine 94 patients, for hyposplenism 100 patients, for...
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