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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Testování nových nanomateriálů pro teranostické aplikace u modelu myši
 Donovalová, Alexandra
Theranostics is connecting two medical branches, diagnostic and therapy. It enables transport of drugs and diagnostic imaging in one step. Nanoparticles, nanotubes, lipozomes or apoferritin can be used as platform for targeted transport. Apoferritin (APO) is a protein from ferritin family, which is characterized by an empty cavity. Is possible encapsulate some cargo (e.g., drug) into this cavity. Encapsulation is done by pH change. There is a possibility to modify APO surface. It causes targeted transport to for example cancer cells. In this study, process of preparation of targeted nanotransporter based on APO is described; next, its characterization by in vitro experiments is shown. The prepared targeted nanotransporter delivered drug to cancer cells and in the same time was decreased toxicity on surrounding tissue and organs.
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Žížala hnojní (Eisenia fetida) a kvantové tečky
 Donovalová, Alexandra
Biosynthesis is one of the new possibilities for the synthesis of nanoparticles. Among others, biosynthesis serves as a natural defense against heavy metal ions. The organisms capable of biosynthesis are bacteria, funghi, yeasts or earthworm manure (Eisenia fetida). Earthworm is able to biosynthesis at chloragogenous tissue, which ser-ves as a liver. In our study the ability of earthworm manure makes biosynthesis has be-en evaluated. Further, a characterization of synthesized nanoparticles was done with determination of influence of biosynthesis on organism. During the evaluation there has been found that earthworm is able to biosynthesize the CdTe quantum dots with 18 nm size. During the determination of the effect of biosynthesis on organism was showed the presence of metallothionein in organism, which prooving participation of metallothione-in in formation of nanoparticles.
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See also: similar author names
2 Donovalová, Adéla
2 Donovalová, Anna
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