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Molecular Machines in Medicine
 Dědek, Matěj ; Kaleta, Jiří (advisor) ; Hrdina, Radim (referee)
This bachelor thesis is focused on synthesis of light-driven molecular motors and switches, their physical properties and potential utilisation in medicinal chemistry. It is expected, that these molecular machines might possibly in the future serve as mechanical weapons against various cellular pathogens, modulate ion transport and other cellular processes. Within the framework of this thesis were studied preparations of rotors of the molecular machines based on cyclopenta-[a]-naphtalen-1-ones from comercially affordable chemicals and substitution of these rotors on aromatic core was examined. The main effort was put on verification and optimalisation of previously published synthetic processes and on isolation and characterisation of side products of the reactions. Another aim of this work was synthesizing building blocks of a molecular motor model, imitating a light-driven bacterial flagellum.
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See also: similar author names
4 DEDEK, Michal
2 Dedek, Martin
2 Dědek, Martin
4 Dědek, Michal
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