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Quantitative computed tomography Šalplachta, Jakub ; Keckes, Jozef (referee) ; Batenburg, Joost (referee) ; Kaiser, Jozef (advisor) Hlavním cílem této práce je prostudovat, prozkoumat a případně posunout dále oblast kvantitativní počítačové tomografie (QCT) se specifickým zaměřením na laboratorní submikronový CT systém Rigaku nano3DX. Tato práce se zabývá oběma aspekty QCT, kterými jsou akvizice kvantitativních CT dat a využití CT dat pro kvantitativní analýzu. Pokud jde o první aspekt, specifický důraz je kladen na posouzení současných technologických limitů submikronového CT, kde jsou studovány tomografické artefakty způsobené právě technickými nedostatky a navrženy optimální redukční strategie. Také praktické aspekty spojené s implementací spektrálního CT ve formě dual-targetového CT (DTCT) pomocí systému Rigaku nano3DX jsou řešeny vývojem specializovaných metodologií pro akvizici a registrace dat. Pro kvantitativní analýzu CT dat byly vyvinuty dvě nové metody. Jedna z metod byla speciálně navržena pro analýzu porozity vzorků vyrobených metodou 3D-tisku a to s ohledem na klíčové aspekty zpracování tomografických dat, díky čemuž je tato metoda objektivní a reprodukovatelná. Druhá metoda byla speciálně navržena pro kvantitativní hodnocení 3D modelů biologických tubulárních systémů a byla prakticky testována na myším modelu Alagilleova syndromu. Detailed record

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