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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Mapping of the cell population expressing Sonic hedgehog during the embryonic development of heart
 Břežná, Veronika ; Hovořáková, Mária (advisor) ; Šaňková, Barbora (referee)
Sonic hedgehog is one of three members of the Hedgehog family, whose signaling pathway plays a crucial role in controlling the development of vertebrates. Sonic hedgehog has an important role in organizing the developmental processes of majority of organ systems. Interestingly, its direct expression or a contribution of cell lineages expressing this signaling molecule in the myocardium has never been described. The aim of this work was to try to detect the cells that expressed Sonic hedgehog directly in the heart tissue with a focus on the myocardium. We monitored these cells from embryonic day 10.5 to 16.5 and then postnatally. We also evaluated current Sonic hedgehog expression in cardiac tissue from embryonic day 12.5 to embryonic day 15.5. We used the CreLoxP system, X-gal staining, fluorescence and confocal microscopy to detect cell lines expressing Sonic hedgehog. We also assessed the presence of cells that expressed Sonic hedgehog in the developping heart in the past using immunohistochemistry. According to our results, the presence of a descendant cell lineage expressing Sonic hedgehog in the past was demonstrated prenatally and postnatally in the mouse myocardium. The performed analysis shows that these cells can be detected in cardiac tissue from embryonic day 10.5 till the postnatal...
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Facial development and its molecular background
 Břežná, Veronika ; Hovořáková, Mária (advisor) ; Hrubá, Eva (referee)
This bachelor thesis is an overview of the most important developmental and molecular milestones in the embryonic development of the human head and face and it brings a comprehensive overview of the latest knowledge in developmental and molecular biology of craniofacial structures with focus on the fusion of facial processes. During early embryogenesis the most important developmental changes take place in the cranial area. This period is the most susceptible period for defects and malformations formation. The most common defect in the craniofacial region is the cleft lip and/or palate occurring alone (non- syndromic) or as a part of a syndrome (syndromic). The most common reason of the cleft formation is the insufficient proliferation in the facial processes and palatal shelves, which is caused by the incorrect expression of genes or receptors of these genes whose function can be studied on the mouse and chick models. The present thesis summarizes also the knowledge of etiology of orofacial clefts in the context of new findings about the fusion of facial processes and ossification in the cleft area. Improvement of our knowledge of facial development and defects associated with it is important for accurate prenatal diagnosis and successful treatment of patients, whose problems may not only be...
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