|
| |
|
|
The effect of nutrition on bone metabolism
Švejkovská, Klára ; Živná, Helena (advisor) ; Horák, Pavel (referee) ; Kutílek, Štěpán (referee)
The effect of nutrition on bone metabolism The bone has a function for support and protection, and is also a place for hematopoiesis and for mineral homeostasis. The subject of interest of this thesis is to evaluate the effect of chosen proteins, amino acids, iron and the conditions such as long-term under-nutrition, short-term starving and repeated blood withdrawals on the bone parameters - the length and the diameter of the bone, the width of corticalis, and the mechanical properties - resistance to bending, tension and torsion. There were evaluated changes in the concentration of bones markers, changes in the bone mineral density and changes in lean mass and adipose mass in healthy adult males of the Wistar rats . During my doctorate studies I was studying the effect of these components on the bones. In the 1st experiment the rats were fed by the chosen proteins and amino acids: glutamine (GLN), branched-chain amino acids- valine, leucine and izoleucine (BCAA), and caseine (KAS) ad libitum. Further we monitored the effect of one-week realimantation by standard laboratory diet (SLD) after long-term supplementation by the diet enriched by the above mentioned proteins and amino acids. The group fed by SLD ad libitum was the control group. In the 2nd experiment the effect of paired-feeding of the...
|
|
|
Monitoring of bone metabolism affected by selected drugs
Gradošová, Iveta ; Živná, Helena (advisor) ; Broulík, Petr (referee) ; Blahoš, Jaroslav (referee)
Monitoring of bone metabolism affected by selected drugs Osteoporosis is one of the most common metabolic bone diseases, which belong to civilization diseases, and is a major health and socioeconomic problem, particularly in the older age groups. Cardiovascular diseases are one of the great problems of our society and a leading cause of death worldwide. The major risk factors include hypercholesterolemia and arterial hypertension, which can be effectively reduced by several groups of drugs. At the present, not much attention has been paid to whether or how these drugs affect bone metabolism. With increasing age, people are more likely to develop hypertension and hypercholesterolemia with progressive loss of bone leading to osteoporosis. Many studies have suggested that antihypertensive and hypolipidemic drugs in some way influence bone metabolism. The subject of the present thesis was to investigate the effect of selected, frequently prescribed antihypertensive drugs (amlodipine, metoprolol), and hypolipidemic drugs (ezetimibe, atorvastatin) on bone metabolism in healthy male Wistar albino rats and in rats after orchidectomy (Wistar and spontaneously hypertensive rats). During my postgradual study, three experiments in rats with above mentioned drugs were performed. In the first experiment, drugs...
|
|
|
The effect of nutrition on bone metabolism
Švejkovská, Klára ; Živná, Helena (advisor) ; Horák, Pavel (referee) ; Kutílek, Štěpán (referee)
The effect of nutrition on bone metabolism The bone has a function for support and protection, and is also a place for hematopoiesis and for mineral homeostasis. The subject of interest of this thesis is to evaluate the effect of chosen proteins, amino acids, iron and the conditions such as long-term under-nutrition, short-term starving and repeated blood withdrawals on the bone parameters - the length and the diameter of the bone, the width of corticalis, and the mechanical properties - resistance to bending, tension and torsion. There were evaluated changes in the concentration of bones markers, changes in the bone mineral density and changes in lean mass and adipose mass in healthy adult males of the Wistar rats . During my doctorate studies I was studying the effect of these components on the bones. In the 1st experiment the rats were fed by the chosen proteins and amino acids: glutamine (GLN), branched-chain amino acids- valine, leucine and izoleucine (BCAA), and caseine (KAS) ad libitum. Further we monitored the effect of one-week realimantation by standard laboratory diet (SLD) after long-term supplementation by the diet enriched by the above mentioned proteins and amino acids. The group fed by SLD ad libitum was the control group. In the 2nd experiment the effect of paired-feeding of the...
|
|
|
Monitoring of bone metabolism affected by selected drugs
Gradošová, Iveta ; Živná, Helena (advisor) ; Broulík, Petr (referee) ; Blahoš, Jaroslav (referee)
Monitoring of bone metabolism affected by selected drugs Osteoporosis is one of the most common metabolic bone diseases, which belong to civilization diseases, and is a major health and socioeconomic problem, particularly in the older age groups. Cardiovascular diseases are one of the great problems of our society and a leading cause of death worldwide. The major risk factors include hypercholesterolemia and arterial hypertension, which can be effectively reduced by several groups of drugs. At the present, not much attention has been paid to whether or how these drugs affect bone metabolism. With increasing age, people are more likely to develop hypertension and hypercholesterolemia with progressive loss of bone leading to osteoporosis. Many studies have suggested that antihypertensive and hypolipidemic drugs in some way influence bone metabolism. The subject of the present thesis was to investigate the effect of selected, frequently prescribed antihypertensive drugs (amlodipine, metoprolol), and hypolipidemic drugs (ezetimibe, atorvastatin) on bone metabolism in healthy male Wistar albino rats and in rats after orchidectomy (Wistar and spontaneously hypertensive rats). During my postgradual study, three experiments in rats with above mentioned drugs were performed. In the first experiment, drugs...
|
|
|
Monitoring of bone metabolism affected by selected drugs
Gradošová, Iveta ; Živná, Helena (advisor) ; Broulík, Petr (referee) ; Blahoš, Jaroslav (referee)
Monitoring of bone metabolism affected by selected drugs Osteoporosis is one of the most common metabolic bone diseases, which belong to civilization diseases, and is a major health and socioeconomic problem, particularly in the older age groups. Cardiovascular diseases are one of the great problems of our society and a leading cause of death worldwide. The major risk factors include hypercholesterolemia and arterial hypertension, which can be effectively reduced by several groups of drugs. At the present, not much attention has been paid to whether or how these drugs affect bone metabolism. With increasing age, people are more likely to develop hypertension and hypercholesterolemia with progressive loss of bone leading to osteoporosis. Many studies have suggested that antihypertensive and hypolipidemic drugs in some way influence bone metabolism. The subject of the present thesis was to investigate the effect of selected, frequently prescribed antihypertensive drugs (amlodipine, metoprolol), and hypolipidemic drugs (ezetimibe, atorvastatin) on bone metabolism in healthy male Wistar albino rats and in rats after orchidectomy (Wistar and spontaneously hypertensive rats). During my postgradual study, three experiments in rats with above mentioned drugs were performed. In the first experiment, drugs...
|
|
| |
|
| |
guest ::
