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The effect of ceramide structure on the behavior of thin films modeling the skin barrier.
Šustrová, Terezie ; Pullmannová, Petra (advisor) ; Kováčik, Andrej (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Student: Terezie Šustrová Mentor: Mgr. Petra Pullmannová, Ph.D. Title of Diploma Thesis: The effect of ceramide structure on the behavior of thin films modeling the skin barrier The skin barrier is essential for human survival on dry land, it is located in the uppermost layer of the skin, in the stratum corneum (SC). SC consists of corneocytes that are surrounded by an oligolamellar lipid matrix. The main components of the SC lipids are ceramides (Cer), fatty acids (FFA) and cholesterol (Chol). They are found in the SC in a ratio of 1:1:1. This ratio is essential for epidermal homeostasis. Any change in this ratio may lead to disruption of the barrier function, e.g. to the development of atopic dermatitis or psoriasis. These lipids prevent excessive loss of water from the body and the entry of undesired substances from the external environment into the body. The lipid matrix forms a typical lamellar arrangement in the skin. Lipids form structures with a long periodicity phase - LPP (d ~ 13 nm), with a short periodicity phase - SPP (d ~ 6 nm) and a separated Chol phase (d ~ 3,4 nm). The molecules are organized with each other in a lateral arrangement that can be orthorhombic, hexagonal, or...
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