|
|
Determination of the plasticity of mannitol
Šulková, Petra ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Šulková Petra - Rigorózní práce - 2006 This work deals with the evaluation of plasticity of mannitol by means of the stress relaxation method. Theoretical part of the work describes preparation of the tablets by direct compression, theory of compression and characterizes mannitol. The aim of the work was the determination of mannitol plasticity, following of the influence of the dwell time on residual plasticity and determination of the dependence of residual plasticity on compression force. The plasticity was measured by means of T1 - FPO 50 device. It follows from the results of the work that the increase in dwell time of mannitol tablets lead to the increase of plasticity. Mannitol had the parameter A 56.62 % and B -0.369% kN-1 .
|
|
|
Determination of the Kinetics of the Crushing Process of Tablets Containing Isosorbide-5-mononitrate
Šulková, Petra ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Šulková Petra - diplomová práce - 2006 The diploma theses deal with the determination of optimal parameters for measurement of the kinetics of destruction on basis of force - displacement record. Theoretical part of the work discusses questions of fillers in direct tablet compression. It describes lactose in detail. Besides it describes the methods of evaluation of mechanical resistance of tablets and parameters destructive process. The aim of the experimental work was the evaluation of the destructive process by differential method without zero setting. The minimum value of preloading and cycle rate was to be determined. The tablets of Isosorbit-5-mononitrate were evaluated. The result of the work was the determination of the optimal parameters for the measurement of mechanical resistance of tablets by means of T1 - FRO 50. Minimum value of preloading is 0.1 N, cycle rate and preloading rate 1.0 mm/s. Simultaneously, it was found out that the decrease in force does not influence destructive force, displacement and energy.
|
|
|
Determination of the Kinetics of the Crushing Process of Tablets Containing Isosorbide-5-mononitrate
Šulková, Petra ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Šulková Petra - diplomová práce - 2006 The diploma theses deal with the determination of optimal parameters for measurement of the kinetics of destruction on basis of force - displacement record. Theoretical part of the work discusses questions of fillers in direct tablet compression. It describes lactose in detail. Besides it describes the methods of evaluation of mechanical resistance of tablets and parameters destructive process. The aim of the experimental work was the evaluation of the destructive process by differential method without zero setting. The minimum value of preloading and cycle rate was to be determined. The tablets of Isosorbit-5-mononitrate were evaluated. The result of the work was the determination of the optimal parameters for the measurement of mechanical resistance of tablets by means of T1 - FRO 50. Minimum value of preloading is 0.1 N, cycle rate and preloading rate 1.0 mm/s. Simultaneously, it was found out that the decrease in force does not influence destructive force, displacement and energy.
|
|
|
Determination of the plasticity of mannitol
Šulková, Petra ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Šulková Petra - Rigorózní práce - 2006 This work deals with the evaluation of plasticity of mannitol by means of the stress relaxation method. Theoretical part of the work describes preparation of the tablets by direct compression, theory of compression and characterizes mannitol. The aim of the work was the determination of mannitol plasticity, following of the influence of the dwell time on residual plasticity and determination of the dependence of residual plasticity on compression force. The plasticity was measured by means of T1 - FPO 50 device. It follows from the results of the work that the increase in dwell time of mannitol tablets lead to the increase of plasticity. Mannitol had the parameter A 56.62 % and B -0.369% kN-1 .
|
guest ::
