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Modulation of cytostatics efficacy in cancer cells by sesquiterpenes
Šmatová, Markéta ; Skálová, Lenka (advisor) ; Schröterová, Ladislava (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Markéta Šmatová Supervisor: Prof. RNDr. Lenka Skálová, Ph.D. Title of diploma thesis: Modulation of cytostatics efficacy in cancer cells by sesquiterpenes Oxaliplatin (OxPt) belongs between the cytostatics regulary used during standard chemotherapy treatment of colorectal cancer. The successful treatment of colorectal cancer is often limited by various side effects of OxPt on healthy tissue as well as by the possible development of drug-resistance. The main aim of this theses is to find out if, sesquiterpenes can affect the antiproliferative activity of OxPt. Sesquiterpenes, natural substances, are the main component of essential oils. In human organism, sesquiterpenes have a wide variety of biological effects especially antibacterial, antifungal, immunomodulatory, inflammatory, antirheumatic, antioxidant, antivirus and antitumor. Our study confirmed the antiproliferative effects of sesquiterpenes α-humulen (HUM), caryophyllene-oxide (CAO), valencene (VAL) and trans-nerolidol (NER) in cell lines of colorectal cancer SW-620 and Caco-2. Testing of combinations of OxPt with each sesquiterpenes proved synergistic effects of sesquiterpenes CAO, VAL and partially HUM with OxPt in cell line...
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Modulation of cytostatics efficacy in cancer cells by sesquiterpenes
Šmatová, Markéta ; Skálová, Lenka (advisor) ; Schröterová, Ladislava (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Markéta Šmatová Supervisor: Prof. RNDr. Lenka Skálová, Ph.D. Title of diploma thesis: Modulation of cytostatics efficacy in cancer cells by sesquiterpenes Oxaliplatin (OxPt) belongs between the cytostatics regulary used during standard chemotherapy treatment of colorectal cancer. The successful treatment of colorectal cancer is often limited by various side effects of OxPt on healthy tissue as well as by the possible development of drug-resistance. The main aim of this theses is to find out if, sesquiterpenes can affect the antiproliferative activity of OxPt. Sesquiterpenes, natural substances, are the main component of essential oils. In human organism, sesquiterpenes have a wide variety of biological effects especially antibacterial, antifungal, immunomodulatory, inflammatory, antirheumatic, antioxidant, antivirus and antitumor. Our study confirmed the antiproliferative effects of sesquiterpenes α-humulen (HUM), caryophyllene-oxide (CAO), valencene (VAL) and trans-nerolidol (NER) in cell lines of colorectal cancer SW-620 and Caco-2. Testing of combinations of OxPt with each sesquiterpenes proved synergistic effects of sesquiterpenes CAO, VAL and partially HUM with OxPt in cell line...
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