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National Repository of Grey Literature 4 records found  Search took 0.00 seconds. 
New Trends in HPLC analysis
 Šillerová, Tereza ; Hájková, Renata (advisor) ; Chocholouš, Petr (referee)
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New Trends in HPLC analysis
 Šillerová, Tereza ; Hájková, Renata (advisor) ; Chocholouš, Petr (referee)
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Determination of Valproic Acid using Capillary Gas Chromatography with Mass Spectrometry Detection
 Šillerová, Tereza ; Kučera, Radim (referee) ; Kastner, Petr (advisor)
Valproic acid is a chemical compound with simple structure and wide therapeutic effect. It is primarily used in treatment of epilepsy, bipolar disorder and rarely in treatment of depress. The serum levels of valproic acid have to be determined due to its narrow therapeutic window and risk of drug-drug interactions. Thus a new sensitive analytical method using capillary gas chromatography with mass spectrometric detection has been developed for determination of valproic acid levels in human serum (caprylic acid used as an internal standard). The results showed that the new method was linear within the range of 0,96 - 967,38 µmol/l, which include the therapeutic range (367 - 693 µmol/l) of valproic acid. This method was compared with formerly established fluorescence polarization immunoassay (FPIA) method for determination of valproic acid levels in human serum (FPIA) by means of the Passing-Bablok regression analysis and Bland & Altman Plot. The statistical analysis confirmed that new method is suitable for determination of levels of valproic acid in real human serum samples. The validated method has been applied to the routine analysis of patient's serum samples.
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Synergism of entomopathogenic nematodes and entomopathogenic fungi
 ŠILLEROVÁ, Tereza
The potential synergism between chosen species of entomopathogenic nematodes (Steinernema arenarium, Steinernema feltiae) and entomopathogenic fungi (Beauveria bassiana, Isaria fumosorosea, Lecanicillium lecanii) is investigated in this study. It is theoretically possible to expect increasing of their efficiency at the collective introduction into environment. Creating of uniform laboratory method which will be possible to use at the research of this interaction system is a part of this study.
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4 ŠILLEROVÁ, Tereza
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