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Studium konformačních efektů vazby ligandu na proteinovou strukturu
Šefců, Oskar ; Novotný, Marian (advisor) ; Hexnerová, Rozálie (referee)
This bachelor thesis aims to provide a comprehensive overview of the effects of ligand binding on the 3D structure of proteins. The focus will be on examples where ligand binding causes a significant conformational change between the structure without the ligand (apo structure) and the structure with the ligand (holo-structure). The thesis will discuss various techniques used to determine the structural changes caused by ligand binding, including X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy. Furthermore, the thesis will provide insight into the structural and functional implications of ligand-induced conformational changes in proteins. Overall, this thesis will serve as a resource for understanding the role of ligand binding in modulating the 3D structure of proteins. Keywords: apo, holo, ligand, conformational change, IDP
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