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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Study of bulk and hydration water in hydrogel systems suitable for medical applications
 Řihák, Marek ; Sovová, Šárka (referee) ; Enev, Vojtěch (advisor)
This bachelor thesis focuses on a preparation of hydrogel systems based on hyaluronan and Septonex and on a design and optimalization of quantitative analysis of hyaluronan and Septonex in a supernatant after gelation. This work compares hydrogels formed from hyaluronan of two different molecular weights. The calibration curves of hyaluronan and Septonex were used to evaluate the experimental data. The thermogravimetric analysis and Fourier-transform infrared spectroscopy were used for the characterization of properties of the samples. The utilisation of the mentioned techniques to study molecular water subpopulations was discussed according to the obtained results.
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Program-controlled freeze drying for the preparation of the delivery system based on hyaluronan and real drugs
 Řihák, Marek ; Sedláček, Petr (referee) ; Enev, Vojtěch (advisor)
The aim of this thesis was to prepare native hyaluronan-based carrier systems using the lyophilisation as a suitable method to ensure an interaction between certain drugs and the polymeric structure which would lead to an increased solubility of hydrophobic drugs. For the preparation of such a system the tert-butyl alcohol was used as a co-solvent with the ability to support hydrophobic effect between the drug and a hydrophobic domain of hyaluronan. Since all polar domains of hyaluronan are located in the equatorial position, the axial position is occupied by hydrogens and therefore the molecule gains the amphiphilic character. Previous studies have confirmed that freeze-drying is a useful method for a carrier system preparation. However, this study focuses on the preparation of such systems with samples of real drugs, which were previously replaced by fluorescence sondes. Since all drug samples have good fluorescence characteristics, the fluorescence spectroscopy was used as the main method to determine the success of the preparation. Other methods included a thermogravimetric analysis and the infrared spectroscopy with Fourier transformation. All the mentioned methods have confirmed that lyophilisation is a useful method for the preparation of the carrier systems with real drugs. Great results have been achieved in the terms of the solubility of freeze-dried systems. In the last step, the co-solvent residues were determined by head-space solid phase microextraction. This method also provided some valuable information and confirmed that tert-butyl alcohol could be found in the lyophilised systems only on very low levels.
Detailed record
Study of bulk and hydration water in hydrogel systems suitable for medical applications
 Řihák, Marek ; Sovová, Šárka (referee) ; Enev, Vojtěch (advisor)
This bachelor thesis focuses on a preparation of hydrogel systems based on hyaluronan and Septonex and on a design and optimalization of quantitative analysis of hyaluronan and Septonex in a supernatant after gelation. This work compares hydrogels formed from hyaluronan of two different molecular weights. The calibration curves of hyaluronan and Septonex were used to evaluate the experimental data. The thermogravimetric analysis and Fourier-transform infrared spectroscopy were used for the characterization of properties of the samples. The utilisation of the mentioned techniques to study molecular water subpopulations was discussed according to the obtained results.
Detailed record

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1 Řihák, Matyáš
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