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Study of the role of glutathione in the anthracycline-induced cardiomyocyte injury
Vávrová, Anna ; Šimůnek, Tomáš (advisor) ; Kvasničková, Eva (referee)
The clinical usefulness of anthracycline antineoplastic drugs has been limited by the risk of serious cardiotoxicity. Its precise mechanisms have not been fully elucidated, although the oxidative stress is widely believed to play a principal role. The anthracycline toxicity to heart may result from its high accumulation in myocardial tissue, richness on mitochondria producing reactive oxygen species and relatively poor antioxidant systems including superoxide dismutase, catalase and glutathione peroxidase. This study is focused on the role glutathione in daunorubicin (DAU)-induced cardiotoxicity both in vitro and in vivo. Total, reduced and oxidized glutathione (GSH/GSSG) have been determined by a spectrophotometric method using dithiobis(2-nitrobenzoic acid) in DAU (0.1 - 10 µM) - exposed H9c2 cardiomyoblast cell line and heart tissue from daunorubicin-treated rabbits (3mg/kg weekly, 10 weeks). In H9c2 cells, DAU induced significant toxicity (IC50=0.48 µM), levels of total glutathione were slightly but insignificantly decreased, the levels of oxidized glutathione were unafected. Neither buthionine sulfoximine (BSO, an inhibitor of glutathione synthesis) nor 2-oxo-4-thiazolidine-carboxylic acid (OTC, a glutathione synthetic precursor) had any significant effects of DAU cytotoxicity. This contrasted...
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Corporate identity of student theatre festival
Vávrová, Anna ; Chorý, Tomáš (referee) ; Rajlich, Jan (advisor)
The thesis deals with the creation of corporate indentity of student festival Salon původní tvorby at the Theatre Department of Janacek Academy of Brno. The objective of the thseis is to assess the theoretical rules of creating corporate identity and then to apply them on creating the logo and logotype of the festival that could be used for any theme of the festival. Furthermore the thesis creates the design of the actual year, Salon [si ty]. There it attemps mainly for the increase of presentation of the festival and the orientation of the participants. The design follows the ergonomic, constrictional and other rules set up in the theoretical research.
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Design of an electric aromalamp
Vávrová, Anna ; Zvonek, Miroslav (referee) ; Rajlich, Jan (advisor)
The thesis focuses on design of an electric aromalamp in such a way that it would fulfil the basic technical, ergonomic, and aesthetic demands and in the same time bring new perception of the given issue, particularly as far as the general shape interpretation and expression is concerned. The final product should follow the trend of simple design, the focus on a wide scale of potential users, and last, but not least, it should follow the teaching about harmonic interior design, of which the aromalamp is a part.
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Empty Nest Syndrome as a Factor Affecting Life of Women in Todays Society
VÁVROVÁ, Anna
This thesis is just theoretical, divided into four main parts. In the first part the basic concepts are allotted. The second and the third part feature women in mean and late adult age. These two parts follow physiological, but especially psychical and social changes, that go with these phases of women's adult age. The fourth part of thesis is devoted to empty nest syndrome as a serious psychosocial problem of women between the ages of 40 {--} 60 years. It results from previous parts and describes time period, cause of uprise of empty nest syndrome and possible effects. In the last chapter we can find some possibilities how to solve these phenomenon.
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