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Receptor for Nicotinic Acid
Suchánková, Marie ; Fendrich, Zdeněk (advisor) ; Hronek, Miloslav (referee)
Nicotinic acid belongs to the drugs with anti-hyperlipidemia effects. It lowers levels of both cholesterol and triglycerides and increases the level of HDL. The benefit features of this vitamin are accompanied with the side effects of flushing, mainly, that have very negative influence to patient compliance. Independently, T. Soga and A. Wise have discovered the G-protein-coupled receptor GPR109A (HM74A in humans, PUMA-G in mice) as the receptor for nicotinic acid. This elucidation opened the way to elucidate the molecular identification of the mechanism of nicotinic acid-induced flushing. We have done several experiments with PUMA-G double-knockout mice which lacking the PUMA- G receptor. First of all, we have established the method for monitoring the flushing response after the administration of nicotinic acid and acipimox, its derivative with similar effect on the lipid metabolism. From our results, it implied that nicotinic acid and acipimox causes flushing response via the receptor PUMA-G. Thus we could say that PUMA-G receptors are involved in both lipid- lowering mechanism and flushing-mechanism. It has been postulated that NSAIDs can diminish the occurring flush response in the patients. Our experiments with COX-1 -/- clearly showed that COX-1 is one of the crucial enzymes in the nicotinic...
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Vliv stáří chmelnice na druhové složení plevelů
Suchánková, Marie
Bachelor thesis occupies with weed evaluation in selected hop plants. The literary part is focused on hop production in the Czech Republic, botanical and biological characteristics of hops. Both perennial, both in the elderly and in the younger, fytocenological relevé were prepared. The evaluation was conducted in three deadlines in April, June and August 2017. The values obtained were statistically evaluated by DCA and CCA analyzes.The observation took place at the agricultural cooperative in Kokora. Two weeds have been recorded as 26 weeds. In the older hopper there were Solanum nigrum, Tripleurospermum inodorum, Galinsoga parviflora, Elytrigia repens, Atriplex patula, Rumex obtusifolius, Lmium amplexicaule, Holosteum umbellatum. In the younger hopper there was mainly Persicaria lapathifolia.
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Receptor for Nicotinic Acid
Suchánková, Marie ; Fendrich, Zdeněk (advisor) ; Hronek, Miloslav (referee)
Nicotinic acid belongs to the drugs with anti-hyperlipidemia effects. It lowers levels of both cholesterol and triglycerides and increases the level of HDL. The benefit features of this vitamin are accompanied with the side effects of flushing, mainly, that have very negative influence to patient compliance. Independently, T. Soga and A. Wise have discovered the G-protein-coupled receptor GPR109A (HM74A in humans, PUMA-G in mice) as the receptor for nicotinic acid. This elucidation opened the way to elucidate the molecular identification of the mechanism of nicotinic acid-induced flushing. We have done several experiments with PUMA-G double-knockout mice which lacking the PUMA- G receptor. First of all, we have established the method for monitoring the flushing response after the administration of nicotinic acid and acipimox, its derivative with similar effect on the lipid metabolism. From our results, it implied that nicotinic acid and acipimox causes flushing response via the receptor PUMA-G. Thus we could say that PUMA-G receptors are involved in both lipid- lowering mechanism and flushing-mechanism. It has been postulated that NSAIDs can diminish the occurring flush response in the patients. Our experiments with COX-1 -/- clearly showed that COX-1 is one of the crucial enzymes in the nicotinic...
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