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Evaluation of flow and consolidation properties of magnesium aluminometasilicate
Dzámová, Pavlína ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph. D. Student: Mgr. Pavlína Dzámová Title of Thesis: Evaluation of flow and consolidation properties of magnesium aluminometasilicate Aluminometasilicates belong to modern excipients used in many pharmaceutical dosage forms. Recently, they have been used as the drug carriers especially for their high adsorption capacity. In this work, the bulk and consolidation properties of Neusilin US2 were evaluated. Apart from the traditional methods such as the bulk density and tapped density, the angle of repose, the flow rate through the outlet of a hopper, the helium pyknometry was used for the measurement of the true density. The flow function and the angle of internal friction was estimated by the translation Jenike shear tester. The particles of Neusilin US2 showed high porosity (more than 90 %) and low bulk density. Good to excellent bulk properties were detected.
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Oxadiazoles as potential drugs
Dzámová, Pavlína ; Kučerová, Marta (advisor) ; Zitko, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Candidate: Pavlína Dzámová Supervisor: PharmDr. Marta Kučerová, Ph. D. Title of diploma thesis: Oxadiazoles as Potential Drugs Due to the increasing resistence of bacteria and fungi against conventional drugs, it is imperative to design and develop new antibacterial or antifungal agents. In the theoretical part of this diploma thesis,I focused on the biological activities of 1,2,4- oxadiazoles, that are known as the compounds with promising future in this direction. They are very important heterocyclic compounds with various bioactivities, such as tyrosine kinase inhibition, muscarinic agonism, histamine H3 antagonism, anti- inflammatory, antitumoral, antimicrobal and monoamine oxidase inhibition. Methodical part resumes the most important procedures for the preparation of 1,2,4-oxadiazoles. In the experimental part of this study, six new oxadiazole derivates have been synthesized. 5-Methyl-3-pyrazin-2-yl-1,2,4-oxadiazoles variably alkylated in position 5 of the pyrazine ring resulted from cyclization of corresponding pyrazin-2- karboximidamides with acetanhydride. Starting compounds for cyclization were available in our laboratory. In case of absence, they were prepared by radical alkylation of pyrazincarbonitrile and by...
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Evaluation of flow and consolidation properties of magnesium aluminometasilicate
Dzámová, Pavlína ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph. D. Student: Mgr. Pavlína Dzámová Title of Thesis: Evaluation of flow and consolidation properties of magnesium aluminometasilicate Aluminometasilicates belong to modern excipients used in many pharmaceutical dosage forms. Recently, they have been used as the drug carriers especially for their high adsorption capacity. In this work, the bulk and consolidation properties of Neusilin US2 were evaluated. Apart from the traditional methods such as the bulk density and tapped density, the angle of repose, the flow rate through the outlet of a hopper, the helium pyknometry was used for the measurement of the true density. The flow function and the angle of internal friction was estimated by the translation Jenike shear tester. The particles of Neusilin US2 showed high porosity (more than 90 %) and low bulk density. Good to excellent bulk properties were detected.
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Oxadiazoles as potential drugs
Dzámová, Pavlína ; Kučerová, Marta (advisor) ; Zitko, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Candidate: Pavlína Dzámová Supervisor: PharmDr. Marta Kučerová, Ph. D. Title of diploma thesis: Oxadiazoles as Potential Drugs Due to the increasing resistence of bacteria and fungi against conventional drugs, it is imperative to design and develop new antibacterial or antifungal agents. In the theoretical part of this diploma thesis,I focused on the biological activities of 1,2,4- oxadiazoles, that are known as the compounds with promising future in this direction. They are very important heterocyclic compounds with various bioactivities, such as tyrosine kinase inhibition, muscarinic agonism, histamine H3 antagonism, anti- inflammatory, antitumoral, antimicrobal and monoamine oxidase inhibition. Methodical part resumes the most important procedures for the preparation of 1,2,4-oxadiazoles. In the experimental part of this study, six new oxadiazole derivates have been synthesized. 5-Methyl-3-pyrazin-2-yl-1,2,4-oxadiazoles variably alkylated in position 5 of the pyrazine ring resulted from cyclization of corresponding pyrazin-2- karboximidamides with acetanhydride. Starting compounds for cyclization were available in our laboratory. In case of absence, they were prepared by radical alkylation of pyrazincarbonitrile and by...
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