Rigorous theses

Rigorous theses 15,457 records found  previous11 - 20nextend  jump to record: Search took 0.01 seconds. 
Design, synthesis and evaluation of heterocyclic compounds with potential antimicrobial activity IV
Fekri, Amir Hossein ; Zitko, Jan (advisor) ; Miletín, Miroslav (referee)
(English) Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Thesis title: Design, synthesis and evaluation of heterocyclic compounds with potential antimicrobial activity IV Candidate: Amirhossein Fekri Supervisor: doc. PharmDr. Jan Zitko, Ph.D. Consultant: Mgr. Vinod S. K. Pallabothula Tuberculosis has remained one of the deadliest infectious diseases worldwide caused by a single infectious agent, the rapid growth of resistance to anti-tubercular drugs hinders the successful control and treatment of TB worldwide, which challenges the scientific community to develop new drugs to improve currently available treatment. This diploma thesis represents the design, synthesis, and biological evaluation of two series of compounds including cyclized (pyrazine- oxazinone) and carboxamide derivatives as potentially active antimycobacterial agents sharing a pyrazine core as common structural features that could potentially target mycobacterial aspartate decarboxylase (PanD) and prolyl-tRNA synthetase (mtProRS), respectively. Synthesis of final compounds was achieved through individual reaction steps involving acylation of methyl 3-aminopyrazine-2-carboxylate for preparation of a common intermediate which in turn was used for the...
Evaluation of the rationality of prescribing of selected potentially inappropriate medications in ambulatory geriatric patients (II.)
Želivská, Nela ; Fialová, Daniela (advisor) ; Pokladníková, Jitka (referee)
Institution/Department: Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Social and Clinical Pharmacy Title of diploma thesis: Evaluation of the rationality of prescribing of selected potentially inappropriate medications in ambulatory geriatric patients (II.) Diploma thesis supervisor: Assoc. Prof. Daniela Fialova, PharmDr. Ph.D. Author: Nela Zelivska Introduction: The percentage of geriatric patients in the population is constantly increasing, thus the importance and need for knowledge of rational geriatric pharmacotherapy in everyday clinical practice is also on the rise. Polymorbidity and polypharmacotherapy are very common in geriatric patients, for this reason it is also necessary to regularly review drug regimens in older age and address potential drug- related problems. Criteria for potentially inappropriate medications in the aged (PIMs) have been defined by expert groups as a helpful tool to improve the rationality of drug prescribing in older adults. The risks of PIMs in older patients often outweigh their benefits or there is insufficient scientific evidence of adequate efficacy/safety of these drugs in older adults, for which reason the use of PIMs in older patients should be limited and their rationality of prescribing regularly monitored. This diploma thesis...
Changes of the catecholamins, serotonine and lactate levels during sport climbing on a climbing wall depending on the leader climber's style of belaying
Strnadová, Kateřina ; Vomáčko, Ladislav (advisor) ; Bunc, Václav (referee)
Title: Changes of the catecholamins, serotonine and lactate levels during sport climbing on a climbing wall depending on the leader climber's style of belaying. Goals: The Goal of this thesis is to build on the bachelor thesis and develop its goals. The research is focused on a detection of blood hormonal changes before performance, right after it and after a 15- minute pacification depending on a style of a personal profile and style of belaying of the climbers. Hormonal changes have been compared during the performance on two climbing routes of the same difficulty and different styles of belaying. Methods: The randomized research sample consisted of 10 women, climbers, who climbed two routes using the OS (on sight) style on the level of maximum effort. One of the routes was climbed with clipping in protection points against the second route, which was climbed without protection points. The research was performed using a blood collection from v. brachialis and spinning off the blood plasma of the collected blood. Lactate was determined on Siemens Adria 1800 in a routine laboratory, serotonine was determined using LS-MS/MS with a gradient elution. Catecholamines were determined using LS-MS/MS with an isocratic elution. The survey composed of three psychological questionnaires (DMV, RCAI, Eysenck's...
Alkaloids from wood of the species Liriodendron tulipifera L. and their biological activity
Klíčová, Anna ; Hošťálková, Anna (advisor) ; Chlebek, Jakub (referee)
Klíčová A.: Alkaloids from wood of the species Liriodendron tulipifera L. and their biological activity. Diploma thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department: Pharmaceutical Botany, Hradec Králové, 2018. Supervisor: PharmDr. Anna Hošťálková, Ph.D. Key words: Liriodendron tulipifera, secondary metabolites, alkaloids, biological activity Alzheimer's disease (AD) is the most common type of dementia. It is neurodegenerative disorder. Patients suffer from cognitive disorder in combination with aphasia, apraxia or disorders of executive functions, which leads to exacerbation of working or social skills. Nowadays, there exist no casual treatment for AD, and that is why the intense research is still waging. Currently there are available remedies, which can slow down progress of AD. These drugs includes also natural substances. An alkaloid extract of Liriodendron tulipifera L. wood showed promising inhibition of human cholinesterases in a preliminary testing. These results were the reason why this extract has been chosen for further isolation of single alkaloids and identification of their biological activity. Isolation was made by column chromatography with step gradient elution. Then was used preparative TLC to isolate single alkaloids. Identification of alkaloids was...
Ideal or mirror? Principles and ideas of the May 9 Constitution and the 1960 Constitution and their reflection in criminal and civil law
Blažková, Tereza ; Šouša, Jiří (referee)
- Ideal or mirror? Principles and ideas of the May 9 Constitution and the 1960 Constitution and their reflection in criminal and civil law. Presented thesis entitled "Ideal or mirror? The principles and ideas of the Constitution of May 9 and the Constitution of 1960 and their reflection in criminal and civil law" deals with the issue of constitutional development on the territory of Czechoslovakia after 1945. The work has several levels. It examines the role of the constitution in the process of creating other legal regulations and asks questions about the role of the constitution in society in relation to its ideological anchoring. It also focuses on examining the influence of communist ideology in constitutional law, especially in the process of adopting the constitution. The work also affects the role of constitutional values within the codification processes that followed the adoption of the May 9th Constitution and the 1960 Constitution. Criminal law and civil law were chosen as examples of these codification processes. Conceptually, the work is divided into four basic chapters. The first part of the thesis includes the definition of the topic, including the methodology, and also outlines the sources and materials used for the preparation of the dissertation. Due to the definition of the...
Analysis of drug administration by nurses in health facility VIII
Vaclaviková, Iveta ; Malý, Josef (advisor) ; Šorf, Aleš (referee)
Author: Iveta Vaclaviková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Medication errors contribute significantly to the occurrence of adverse events that can impact patient health. The aim of this thesis was to analyze the administration of drugs to patients hospitalized by nurses in one of four studied health facilities in the South Bohemia region in the surgical, internal medicine and aftercare wards. Methods: This diploma thesis is part of an observational-interventional study, in years 2020- 2023. Observations took place in internal medicine, surgery and aftercare wards. Collection of data was held from 23th May to 26th May 2022 by a multidisciplinary team made up of a pharmacist and a nurse by direct observation method. These following data were collected: information about pacient (e.g., gender, age, and any medications taken), information about the nurse by whom the medications were administered (e.g., age, years of experience, highest educational attainment), and information recorded during the actual administration of the medications (e.g. nurse compliance with hygiene requirements; patient identification; checking originality of the drug; whether the...
Assessment of the intake of vitamins in pregnant women
Tkáčiková, Jana ; Kovařík, Miroslav (advisor) ; Kudláčková, Zděnka (referee)
2. ABSTRACT Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author : Jana Tkáčiková Tutor: PharmDr. Miroslav Kovařík, Ph.D. Title: Assessment of vitamins intake in pregnant women Theoretical base and aim of the thesis: The topic of the diploma thesis is women's nutrition during pregnancy. The aim of the work was to evaluate the intake of vitamins in pregnant women and the subsequent comparison of the results obtained over the period with the recommended daily allowances (RDA) as well as the evaluation of how the addition of supplementation to the diet affected the intake of vitamins. Methods: During the study 10 pregnant women with physiological pregnancies were examined. The observed women were in the age range of 25 - 30 years and their investigation took place in three periods; G1 (17th - 27th week of pregnancy), G2 (28th - 35th week of pregnancy) and G3 (36th - 38th week of pregnancy). The study ran from February 2020 to January 2021. The intake of individual vitamins was evaluated on average every 1 week. We also detected the supplementation intake. The obtained data were processed using computer programmes NutriDan and Microsoft Office Excel 2019. The results were compared with RDA. Results: The examination results indicated that the intake of...
Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers
Preiss, Přemysl ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers Author: Přemysl Preiss Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Endoprosthetic surgeries are demanding orthopedic surgeries rarely associated with complications, that can be fatal. One is periprosthetic joint infection (PJI), whose risk can be decreased by antibiotic prophylaxis (AP). The aim of this effort was to describe trends in endoprosthetic surgeries of the knee and the hip, their complications and options of diagnostics in the theoretical part. The aim of the practical part was to analyze prognostic features of chosen laboratory parameters on postoperative infections, respectively on postoperative complications. Methods: This prospective study started in March 2020 and data gathering took place until 28. 3. 2022 at the Ortopedic Clinic of the University Hospital Hradec Králové. Patients, who were included in the study, fulfilled the preliminary criteria, e.g. age ≥ 18 years, patient undergoing total hip or knee arthroplasty at the time of the study and giving the informed consent to the study. Data were gathered from...
The acute effect of percusive therapy on postural stability and muscle activation in people with chronic ankle instability and controls
Michal, Lukáš ; Hank, Mikuláš (advisor) ; Šorfová, Monika (referee)
F2 = 0.15; with a significance level of α = 0.05 and a test power of β = - - (p=0.014) CAI NO PRE (CNP) and HEALTHY YES POST (HYPO) and between the CAI NO POST (CNPO) vs. HYPO (p=0.05). The only statistical difference (p=0.045) within CAI group was found in CNP vs. CAI YES POST (CYPO). Since there was no significant difference in the pre-tests between any of the groups (CNP and CYP), we may confirm the hypothesis of the effect of PT in postural stability (OE) test. In contrast, in the CE test, this change was observed between groups CNPO and CYPO (p=0.05). Since there was no pre-test difference between the CAI groups in CE parameter, we may also confirm the effect of PT in CE test, even though the intragroup outcomes between pre and post-test weren't sensitive enough to find significant (p<0.05) improvement. Unilateral postural stability surveyed in relation to PT showed increased bilateral asymmetry between DOM and NON in Flamingo test (expressed as %). Especially HYPO group revealed risen asymmetry after PT when compared to CNPO (p=0.007), CNP (p=0.015) and CYPO (p=0.05). Key finding was measured significant difference in intragroup parameter between HYP vs. HYPO (p=0.014), which confirmed increased bilateral asymmetry in unilateral postural stability HEALTHY subjects before and after use of PT, but not...

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