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Vliv praziquantelu na raná vývojová stádia amura bílého
BÁRTOVÁ, Lucie
Praziquantel belongs to a group of medicines called anthelmintics, which are used to control parasitic infections. The aim of this study was to assess the effect of praziquantel on hatching, mortality, ontogenetic development, growth, oxidative stress and antioxidant enzyme activity in the early life stages of grass carp (Ctenopharyngodon idella). To assess the toxicity of praziquantel for the early life stages of grass carp, an embryo-larval fish toxicity test (OECD test no. 210) was used. The toxic effects of praziquantel were investigated when exposed to four concentrations (1 mg/l, 2 mg/l, 4 mg/l, 6 mg/l) for 29 days. A negative effect on curling was not observed in any group. A negative effect on mortality was observed in fish exposed to the concentrations of praziquantel 2 mg/l, 4 mg/l and 6 mg/l. Groups exposed to praziquantel concentrations of 4 mg/l and 6 mg/l died during the test period. A negative effect on ontogenetic development was observed in fish exposed to praziquantel concentrations of 4 mg/l and 6 mg/l. A negative effect of praziquantel on the activity of glutathione-S-transpherase was observed in the group exposed to a praziquantel concentration of 2 mg/l. A concentration of 1 mg/l praziquantel can be considered as a safe concentration for the early life stages of grass carp in the case of long-term exposure.
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