|
|
Electromembrane extraction of amphetamines and cathinones from meconium
Dvořáková, Adéla ; Bavlovič Piskáčková, Hana (advisor) ; Kučera, Radim (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Student: Adéla Dvořáková Supervisor: PharmDr. Hana Bavlovič Piskáčková, Ph.D. Title of diploma thesis: Electromembrane extraction of amphetamines and cathinones from meconium Drug use is one of the long-term problems worldwide. Amphetamines (especially methamphetamine) belong among the most used hard drugs in the Czech Republic. Amphetamines and their structurally similar substances synthetic cathinones are psychostimulants and have a stimulating effect on the central nervous system. They increase the level of dopamine, norepinephrine, and serotonin at the synapses through their reduced reuptake. Drug use during pregnancy does not harm only the mother, but also the fetus and can lead to abnormalities that may occur malformations of fetal organs, delayed fetal development, low birth weight of the newborn, premature birth, or risk of hypoxia. There is also a risk that a newborn will have neonatal abstinence syndrome (NAS). Prenatal drug exposure not only risks complications during pregnancy and childbirth, but also later consequences. Most children have developmental disorders, cognitive problems, and behavioral problems until school age. Therefore, the determination of fetal...
|
guest ::
RSS feed.