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TRC105 effects on development of fibrosis in liver
 Masoumali, Kimia ; Němečková, Ivana (advisor) ; Rathouská, Jana (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences TRC105 effects on development of fibrosis in liver Diploma thesis Hradec Králové 2022 Abstract Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Supervisor: Dr. Ivana Nemeckova, Ph.D. Consultant: M.Sc. Samira Eissazadeh Author: Kimia Masoumali Title of the thesis: TRC105 effects on the development of fibrosis in liver The objective of the thesis Hepatic stellate cells (HSCs) become contractile and proinflammatory myofibroblasts due to constant damage activating α-SMA (ɑ-smooth muscle actin) and ECM (extracellular matrix) components. α-SMA is an isoform of vascular smooth muscle actins that is predominantly produced in vascular smooth muscle cells, is a particular marker for smooth muscle differentiation and hepatocyte activation and contributes to fibrogenesis. GFAP (glial fibrillar acidic protein) is a monomeric intermediate filament (IF) III protein most typically expressed by astrocytes however, the expression of GFAP in vivo in inert stellate cells of the liver has been recognized. It's been proven that GFAP levels in the liver of bile duct ligated mice were heightened. CRIP2 (Cysteine- rich intestinal protein 2) is a member of the LIM proteins...
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