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Perioperative disorders of haemostasis
 Havlůj, Lukáš ; Gürlich, Robert (advisor) ; Ulrych, Jan (referee) ; Procházka, Vladimír (referee)
Introduction: Hemostasis is a part of homeostasis. Its effectiveness is based on the functionality of systems that stop bleeding (primary hemostasis, primary and secondary processes of activation) and fibrinolysis. These processes potentiate and antagonize each other. If external endothelial function and integrity are compromised due to external stimuli, this balance is disturbed and thrombosis or bleeding occurs. Autoregulatory mechanisms are primarily able to normalize these pathophysiological conditions to some extent. However, if the supply of platelets or coagulation factors is depleted, there is a risk of bleeding. Excessive activation of the coagulation cascade with, for example, thrombocytosis can lead to generalized arterial or venous thrombosis. Goal: The main goal of this work is to confirm or refute the hypothesis that the combination of pancreatic mucosal malignancies with discontinuation of chronic antiplatelet therapy is associated with a high risk of thrombosis. Secondary goals were to investigate the effect of long-term antiplatelet therapy on long-term survival and incidence of postoperative complications after pancreatic resections performed for pancreatic malignancies. Methods: This is a retrospective analysis of a prospective registry of patients undergoing surgery for...
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