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Coordinatively unsaturated complexes of macrocyclic amides
 Mojžíšová, Adéla ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
Growing number of citizens in developed countries suffers from neurodegenerative diseases. According to World Health Organization (WHO) dementias affect 55,2 million people and their incidence was doubled over last 20 years. Althought the number of cases is increasing, there is still no effective way for their diagnostics or treatment. With development of implantology, there are still common bacterial diseases as a result of formation of bacterial biofilms on unnatural surfaces. The development of synthetic nucleases which could prevent formation of biofilms is therefore one of the scientific aims. The aim of this bachelor thesis is preparation of polyazamacrocycles which contain amino and amidic functional groups. It can be assumed that these compounds will deprotonate amidic groups after coordination of copper(II) ion. These systems are designed to serve as agents for diagnostics of neurodegenerative diseases using positron emission tomography. In addition, as the complexes are coordinatively unsaturated, they can potentially show an artificial nucleases activity and ability to hydrolytically cleave bacterial biofilms.
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