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The other human red blood groups systems.
Košťálková, Helena ; Řeháček, Vít (advisor) ; Jiroušová, Hana (referee)
Immunohematology studies antigen-antibody reactions and different forms of antigens and antibodies which cause the immunologic reaction of the organism. One of the hazards of blood transfusion is the immunization of individuals. The reaction between antigens and antibodies leads to the binding of the antibodies on the red blood cells membranes and premature degradation. Development of the antibodies affects about 0.1 - 3 % of the human population. Currently 270 blood group systems are known. The National Reference Laboratory for Imunohematology determines the specificity of antibodies against the blood group systems Diego, Yt, Xg, Scianna, Dombrock, Colton, Landsteiner-Wiener, Gerbich, Cromer, Knops, Indian, Ok, John Milton Hagen, HFA and LFA. For the detection of antibodies against the mentioned blood group systems uses the laboratory proper assays and Scarf - an archive of serum with antibodies and red blood cells containing the special antigens. Over the time period since 1st January 2007 till 31st December 2011 102 antibodies against the named blood group systems were detected. Some of these antibodies are clinically significant and subsequent hemoteraphie is very complicated. The most detected antibody was anti-Wr(a), an antibody against the low frequent antigen Wr(a) Diego system.
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