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n-3 polyunsaturated fatty acids in prevention of cardiovascular diseases
 Pavelka, Jan ; Kraml, Pavel (advisor) ; Černá, Milena (referee)
Clinical trials have documented beneficial effect of n-3 polyunsaturated fatty acids on health. Regular dietary intake of n-3 PUFAs decreases the risk of cardiovascular dieseas. n-3 PUFAs may be a safe and effective supplement to drug treatment for reducing the risk of myocardial infarction, arrhythmia and sudden cardiac death. n-3 PUFAs show antiatherogenic properties; e.g. they decrease inflammation, stabilize atherosclerotic plaques and prevent other chronic deseases. For primary prevention it is recommended to eat fish at least twice a week, people with documented coronary heart disease should consume 1 gram of n-3 PUFAs daily. Fish oil and oily fish (losos, tuna, trout, mackerel) are rich in EPA and DHA. ALA is found e.g. in flax seed oil.
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